鞘氨醇1-磷酸受体4研究进展  

The Research Progress of Sphingosine-1-phosphate Receptor 4

作　　者：李超[1] 关颖[1] 龙彩凤[1] 徐以拓 董亚强[1] 阿拉坦高勒[1] 

机构地区：[1]内蒙古大学生命科学学院,内蒙古呼和浩特010021

出　　处：《现代生物医学进展》2016年第26期5196-5200,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(31260210);内蒙古大学2015年国家级大学生创新创业训练计划项目(201510126042)

摘　　要：鞘氨醇1-磷酸(Sphingosine-1-phosphate,S1P)是一种具有生物学活性的溶血磷脂信号分子,在体内通过G蛋白偶联受体(G protein coupled receptor,GPCR)家族鞘氨醇1-磷酸受体(S1P receptors)的5个亚型(S1P1-5)介导多种生物学功能。S1P4也称内皮分化基因受体6(Endothelial differentiation gene receptor 6,Edg-6),主要在淋巴组织和造血组织中表达。近年的研究发现,免疫细胞的迁移分化、骨骼肌前体细胞的迁移、乳腺癌细胞的增殖、TGFβ1介导的抑制骨骼肌细胞凋亡均与S1P4相关。本文将综述近几年来关于S1P介导S1P4的生理病理应答及相关的信号转导机制。Sphingosine-l-phosphate （S1P） is a bioactive lipid mediator that regulates a wide range of cellular processes through its five specific cell-surface G protein-coupled receptors （SIP1-5）. S1P4 is known as endothelial differentiation gene receptor 6 （Edg6）, which mainly be expressed in lymphoid tissue and hematopoietic tissue. SIP plays an essential role in the migration and differentiation of immune cells, in the migration of skeletal muscle precursor cells, and in the proliferation of breast cancer cells and the TGFβ1 induced inhibition of skeletal muscle cells apoptosis. In this article, we review the physiological and pathological processes in response to SIP through S1P4 and related signaling mechanisms.

关 键 词：鞘氨醇1-磷酸受体4 生物学功能 信号通路 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学] Q593[医药卫生—基础医学]