血嗜酸性粒细胞在慢性阻塞性肺疾病急性加重住院患者分层治疗中的临床意义  

Clinical value of eosinophils in the stratified treatment of hospitalized patients with AECOPD

作　　者：吴艳[1] 赵寅滢[1] 范晓东[1] 汪家坤[1] 

机构地区：[1]南京医科大学附属无锡市人民医院呼吸科,江苏无锡214023

出　　处：《临床肺科杂志》2016年第11期1941-1943,共3页Journal of Clinical Pulmonary Medicine

基　　金：江苏省干部保健科研项目(No BJ15009)

摘　　要：目的观察血嗜酸性粒细胞在慢性阻塞性肺疾病急性加重住院患者分层治疗中的作用。方法依据纳入和排除标准,回顾性分析149例入住我院病房的慢阻肺急性加重患者。以入院时血嗜酸性粒细胞2%为cut-off值将患者分为阳性组(血嗜酸性粒细胞≥2%37例)和阴性组(血嗜酸性粒细胞<2%112例),比较两组患者糖皮质激素使用量和住院时间。结果阳性组患者的糖皮质激素使用量(21.2±4.1)mg,住院天数(10.2±2.9)天均显著低于阴性组糖皮质激素用量(36.5±2.6)mg和住院天数(11.3±2.8)天(P<0.05)。结论血嗜酸性粒细胞升高的慢阻肺急性加重住院患者对糖皮质激素治疗的反应快,住院时间短。以血嗜酸性粒细胞作为标志物能更好地指导慢阻肺急性加重住院患者进行分层治疗。Objective To investigation the clinical value of eosinophils in the stratified treatment of hospital-ized patients with AECOPD. Methods We retrospectively analyzed hospitalized patients with AECOPD admitted to our ward. After evaluation of inclusion and exclusion criteria, 149 patients were divided into the positive group （ blood eosinophil count ≥2%, n=37 ） and the negative group （ blood eosinophil count 〈2%, n=112 ） . Their consumption of systemic corticosteroids and duration of hospital stay were compared. Results The positive group had a shorter duration of hospital stay than the negative group did （P〈0. 05）. In addition, the positive group required a lower consumption of systemic corticosteroids （P〈0. 05）. Conclusion The high expression of blood eosinophils in hospitalized patients with AECOPD （ blood eosinophil count ≥2%） predicts a quicker response to systemic cortico-steroids with shorter duration of hospital stay, which suggests that it can better guide the stratified treatment of hospi-talized patients with AECOPD.

关 键 词：慢性阻塞性肺疾病急性加重期 糖皮质激素 嗜酸性粒细胞 住院时间 

分 类 号：R563.9[医药卫生—呼吸系统]