川崎病合并肺炎支原体感染患儿的临床研究  

Clinical Research in Kawasaki Disease with Mycoplasma Pneumoniae Infection in Children

作　　者：周益平[1] 符辰璐 

机构地区：[1]苏州大学附属第三医院、常州市第一人民医院儿科,江苏常州213003

出　　处：《中国血液流变学杂志》2016年第1期95-97,共3页Chinese Journal of Hemorheology

摘　　要：目的：探讨川崎病（Kawasaki disease, KD）患儿合并肺炎支原体（mycoplasma pneumoniae，MP）感染患儿的临床特征。方法回顾性分析于2010年1月—2016年1月收治常州市第一人民医院儿科临床诊断为KD的62例患儿，其中合并MP感染的18例为MP组，其余44例为对照组。比较两组血常规、血沉、C反应蛋白（CRP）、热程等指标。结果 MP组与对照组患儿血白细胞总数、中性粒细胞计数、红细胞压积、血小板计数及血沉差异均没有统计学意义（P＞0.05）。MP组热程较对照组长，CRP高于对照组，两组差异有统计学意义（P＜0.05）。MP组冠状动脉扩张（coronary artery dilated, CAD）发生率高于对照组，两组差异有统计学意义（P＜0.05）。两组均于病程5～10 d使用人血丙种球蛋白（IVIg）1 g/（kg·d），共2 d，阿司匹林50 mg/（kg·d），3次/d口服，MP感染者予阿奇霉素静滴治疗。结论 MP感染可能是KD的诱发原因之一，MP感染可能诱发甚至加重KD患儿的病情，并增加其CAD的概率，从而延长KD的病程并影响其预后。Objective To analyze clinical characteristics and laboratory data of children with mycoplasma pneumoniae （MP） infection of Kawasaki disease （KD）.MethodsTotally 62 KD children with MP infection who were hospitalized from January 2010 to January 2016 in the First People＆#39;s Hospital of Changzhou were divided into KD with MP group （18 children） as the MP group, and KD without MP group （44 children） as the control group. The blood routine, blood sedimentation, CRP and thermal were determined.Results The neutrophilic granulocyte count, leucocyte count, hematocrit, platelet count and erythrocyte sedimentation rate showed no difference between MP group and control group （P〉0.05）. CRP and thermal process showed significant difference between MP group and control group （P〈0.05）. Also the coronary artery expansion （coronary artery dilated, CAD） was signiifcantly different between the two groups （P〈0.05）. In the course of 5 to 10 days, both groups were given intravenous immunoglobulin （IVIG） 1 g/（kg·d） for 2 days, and aspirin 50 mg/（kg·d） （oral administration of three times）. Then the MP group was given azithromycin for the sequential therapy.Conclusion MP infection may be one of the causes of KD. MP infection can induce or worsen the condition of KD children, and increase the risk of coronary artery expansion, ifnally would prolong the course and affect the prognosis.

关 键 词：肺炎支原体 川崎病 儿童 

分 类 号：R725.4[医药卫生—儿科]