有氧运动对原发性高血压患者血浆Apelin-12蛋白影响的研究  

Effect of Aerobic Exercise on Serum Concentration of Apelin-12 in Essential Hypertension Patients

作　　者：罗小雨[1] 钱志远[1] 温仲民[1] 

机构地区：[1]苏州大学附属第二医院预防保健处,江苏苏州215004

出　　处：《中国血液流变学杂志》2016年第1期104-107,共4页Chinese Journal of Hemorheology

基　　金：苏州市体育局2014年度体育科研局管课题（TY2014-108）

摘　　要：目的通过研究原发性高血压患者有氧运动前后血浆Apelin-12蛋白的变化，探讨运动降血压的可能机理。方法选取80例32～59岁轻中度原发高血压患者随机分成运动组和对照组，实验前测定两组血浆Apelin-12蛋白和血管紧张素Ⅱ（AngⅡ）水平，然后运动组完成12周有氧运动，对照组则保留原有生活习惯，然后再测定两组血浆Apelin-12和AngⅡ水平，将获得的数据进行统计学处理。结果12周有氧运动后原发性高血压患者血压较运动前降低；血浆Apelin-12水平较运动前显著升高（P〈O．05），与之相反，血浆AngⅡ水平较运动前显著降低（P〈0．05），且运动组血浆Apelin-12和AngⅡ变化水平呈负相关；对照组实验前后血浆Apelin-12和AngⅡ则无明显变化。结论有氧运动可以下调原发性高血压患者血压，可能是通过提高血浆Apelin水平，下调AngⅡ水平，从而发挥下调血压的作用。Objective To investigate the variability of Apelin-12 protein in patients with essential hypertension （EH） after and before taking the aerobic exercises and discuss the potential treatment principle on hypertension. Methods 80 subjects, aged 32 - 59, with moderate EH are randomly classified into two groups, one aerobic group, the other control group and all subjects＇ Apelin-12 protein and angiotensin Ⅱ （Ang Ⅱ ） are measured. Aerobic group has 12-week aerobic exercises and control group maintain the same lifestyle. 12 weeks later, the amount of Apelin-12 protein and Ang Ⅱ is measured and data analysis are discussed. Results After doing 12 week-aerobic exercise, the blood pressure of patients with EH is decreased and there is a significant increase in Apelin-12 protein （P 〈 0.05） and an obvious decrease in Ang Ⅱ （P 〈 0.05） compared with the control group, whose Apelin-12 protein and Ang Ⅱ remain unchanged. There is a negative correlation between the changes of Apelin-12 and Ang Ⅱ in aerobic group. Conclusion Aerobic exercises are likely to decrease blood pressure of patients with EH through boosting Apelin and decreasing Ang Ⅱ in the plasma.

关 键 词：原发性高血压 有氧运动 Apelin蛋白 血管紧张素Ⅱ(AngⅡ) 

分 类 号：R455[医药卫生—运动医学]