浙江省丽水市职业暴露人群禽流感血清学调查  被引量:5

Serological survey of avian influenza in occupational exposure population in Lishui,Zhejiang

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作  者:叶夏良[1] 雷永良[1] 陈燕飞[1] 王晓光[1] 李羽敏[1] 陈秀英[1] 

机构地区:[1]丽水市疾病预防控制中心,浙江丽水323000

出  处:《中国卫生检验杂志》2016年第18期2703-2705,共3页Chinese Journal of Health Laboratory Technology

基  金:浙江省丽水市公益性技术应用研究项目(2013ZC040)

摘  要:目的了解丽水市职业暴露人群H5、H7、H9亚型禽流感病毒的感染状况,为人感染禽流感防制提供科学依据。方法对职业暴露人群进行问卷调查并采集静脉血分离血清,用马血球红细胞凝集抑制试验检测血清中的H5N1、H5N6、H7N9、H9N2亚型禽流感病毒HI抗体,H7N9亚型禽流感病毒HI抗体效价≥1∶20及H5N1、H5N6、H9N2亚型禽流感病毒HI抗体效价≥1∶40的标本采用微量中和试验检测相应亚型禽流感病毒中和抗体,数据用Excel软件进行统计分析。结果共调查职业暴露人群319人,血清经检测3份标本H7N9亚型禽流感病毒中和抗体阳性,阳性率为0.9%,未检出H5N1、H5N6、H9N2亚型禽流感病毒中和抗体阳性标本。结论丽水市职业暴露人群存在H7N9亚型禽流感病毒感染现象,同时由于城乡活禽交易市场和宰杀加工等场所外环境中存在禽流感病毒,职业暴露人群仍存在感染的风险,必须采取有效措施预防控制职业暴露人群感染发病。Objective To understand the infection status of avian influenza A( H5,H7 and H9) virus in occupational exposure population in Lishui,Zhejiang province,so as to provide scientific basis for the prevention and control of human infected avian influenza A virus( AIV). Methods Questionnaire survey was conducted on the occupational exposure group and the peripheral blood was collected for serum isolation. HI antibodies of H5N1,H5N6,H7N9,H9N2 subtype avian influenza virus in serum were detected with the red blood cell agglutination inhibition test. The samples with HI antibody titer ≥1∶20 of H7N9 subtype and those with HI antibody titer ≥40 of H5N1,H5N6 and H9N2 subtype were detected by micro neutralization test for the neutralizing antibody of avian influenza virus subtypes. Excel software was used to analyze the results statistically. Results A total of 319 occupational exposure persons were investigated. 3 out of 319 sera samples were detected positive for the neutralizing antibody of AIV( 0. 9%),which all were H7N9 subtype. Conclusion There are infection cases of AIV( H7N9 subtype) in the occupational exposure population in Lishui. Meanwhile,AIV does exist in the outer- environment especially in the live poultry markets in urban and rural area,such as the poultry slaughtering and processing sites in Lishui. There is still a risk of infection with AIV to occupational exposure population,so it is necessary to take active measures to prevent and control AIV infection for occupational exposure population.

关 键 词:职业暴露 禽流感病毒 微量中和试验 感染率 血清学调查 

分 类 号:R373.13[医药卫生—病原生物学]

 

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