血液灌流对急性溴敌隆中毒患者体内毒物清除疗效的评估  

Evaluation of the efficacy of hemoperfusion in patients with acute bromadiolone poisoning

作　　者：白丽娜[1,2] 黄昌保[3] 张锡刚 李光 江云 安海英 杨娟 

机构地区：[1]安徽医科大学,合肥230032 [2]解放军307医院急诊科 [3]解放军第532医院急诊科

出　　处：《中国急救复苏与灾害医学杂志》2016年第9期862-864,共3页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的评价血液灌流对急性溴敌隆中毒患者体内毒物清除的疗效。方法回顾性分析本院收治的21例行血液灌流治疗的急性溴敌隆中毒患者的临床资料，比较每次灌流前后血液中溴敌隆浓度变化，观察其单次清除率和总清除率，评价血液灌流的治疗效果。结果21例急性溴敌隆中毒患者的临床症状均有不同程度的改善，治疗前后血液中溴敌隆浓度有明显变化（P〈0．01），随着血液灌流次数增加，血液灌流对毒物的总清除率明显提高（P〈0．01），且单次血液灌流对溴敌隆清除率可高达30％以上。结论在综合治疗的基础上联用血液灌流治疗能有效降低体内溴敌隆浓度，且不良反应少，从而能明显缩短病程，减少再次出血等并发症的发生，因此血液灌流是急性溴敌隆中毒治疗的新手段。Objective To evaluate the efficacy of hemoperfusion （HP） in patients with acute bromadiolone poisoning. Methods Clinical data collected from 21 patients who performed HP for treatment of acute bromadiolone poisoning were retrospectively analyzed. The changes of blood bromadiolone concentrations before and after HP were compared, while the single clearance and the total clearance of HP were detected, The efficacy of HP in patients with acute bromadiolone poisoning was evaluated. Results All patients manifested improved clinical symptoms to various extents and significant differences were found in blood bromadiolone concentration before and after HP （P 〈0.01）. With the increase of HP times, the effects of HP became markedly stronger on the clearance of toxic agents （P 〈0.01）, with a single clearance of over 30%. Conclusion Based on comprehensive therapy, HP can effectively reduce the concentration of blood bromadiolone, with less adverse reactions, leading to greatly shorter duration of treatment and reduced incidence of complications such as recurred bleeding. Therefore, HP can be adopted as a new approach to treat acute bromadiolone poisoning.

关 键 词：血液灌流 溴敌隆中毒 清除效果 

分 类 号：R595.4[医药卫生—内科学]