基于聚N-异丙基丙烯酰胺和苯硼酸的智能胰岛素递送系统的研究进展  

Advances in Smart Insulin Delivery System Based on Poly(N-isopropylacrylamide)and Phenylboronic Acid

作　　者：李佳星[1] 杨磊[1] 范晓光[2] 王战勇[1] 张晶[1] LI Jiaxing YANG Lei FAN Xiaoguang WANG Zhanyong ZHANG Jing(School of Environmental and Biological Engineering, Liaoning Shihua University, Fushun 113001 College of Engineering, Shenyang Agricultural University, Shenyang 110866)

机构地区：[1]辽宁石油化工大学环境与生物工程学院,抚顺113001 [2]沈阳农业大学工程学院,沈阳110866

出　　处：《材料导报》2016年第15期136-143,共8页Materials Reports

基　　金：国家自然科学基金(31570097);辽宁省教育厅科学研究一般项目(L2015307)

摘　　要：糖尿病的治疗期于开发能够实时监测机体血糖浓度,并根据需求精确释放特定剂量胰岛素的载体材料,从而抑制高血糖的出现,同时避免低血糖的发生,以使糖尿病患者的血糖浓度趋于正常范围。温度和葡萄糖双重响应系统的研发无疑为治愈糖尿病的终极目标的实现提供了新的契机。综述了近年来以温敏性聚N-异丙基丙烯酰胺(Poly(N-isopropylacrylamide),PNIPAAm)和糖敏性苯硼酸(Phenylboronic acid,PBA)为功能主体的智能胰岛素递送系统的研究进展,包括简单构造材质(宏观凝胶和微凝胶)和复合结构材料(自组装纳米胶束、核壳式微凝胶、空心微球或微囊)等核心主题。The treatment of diabetes lies in developing novel carrier materials,which are expected to have the unique capability of monitoring blood glucose levels continuously and dispensing insulin by individual requirement correctly,thereby inhibiting hyperglycemia and avoiding hypoglycemia.It would eventually normalize the glucose concentrations of diabetes patients.The emergence of the intelligent materials with dual-response to temperature and glucose provides new opportunities for realizing the ultimate goal to effectively switch off diabetes.This review covers the recent development for the smart insulin delivery systems employed in temperature-responsive poly（N-isopropylacrylamide）（PNIPAAm）and glucose-sensitive phenylboronic acid（PBA）,including the substances with simple construction（macroscopic hydrogels and microhydrogels）,and the materials with composite structure（self-assembled nanomicelles,core-shell microgels,hollow microspheres or microcapsules）.

关 键 词：聚N-异丙基丙烯酰胺 苯硼酸 胰岛素控释载体 温度敏感性 葡萄糖敏感性 

分 类 号：O632[理学—高分子化学] O625[理学—化学]