絮凝剂在银杏叶提取液中除杂工艺研究  

Study on Impurity Removal Technology in Extraction Solution of Folium ginkgo by Flocculant

作　　者：陈小明[1,2,3] 梁静华[4] 袁凤[1] 吕宏再 何福林[1] CHEN Xiao-ming LIANG Jing-hua YUAN Feng LV Hong-zai HE Fu-lin(School of chemistry and engineering, Hunan University of Science and Engineering Key Laboratory of Comprehensive Utilization of Advantage Plants Resources in Hunan South, Hunan University of Science and Technology Hunan Heng wei pharmaceutical Co. ,LTD, Yongzhou 425100,China Guilin Sanfin pharmaceutical Co. ,LTD,Guilin 541004,China)

机构地区：[1]湖南科技学院化学与生物工程学院 [2]湖南科技学院湘南优势植物资源综合利用湖南省重点实验室 [3]湖南恒伟药业股份有限公司,永州425100 [4]桂林三金药业股份有限公司,桂林541004

出　　处：《天然产物研究与开发》2016年第9期1422-1426,共5页Natural Product Research and Development

基　　金：湖南省科技计划重点项目:银杏功能成份提取技术成果产业化开发(2015CK3002)

摘　　要：本实验以黄酮醇苷含量为评价指标,筛选硅藻土、明胶、壳聚糖、101果汁澄清剂、ZTC1+1天然澄清剂、活性炭六种澄清剂,分别采用单因素和正交试验法对银杏叶提取液的澄清条件进行工艺优化。结果表明:银杏叶提取液的最佳澄清条件为明胶做澄清剂,每10 g生药加1%明胶溶液3 m L,浓缩液药比为6∶1(m L/g)、p H为5.5、温度为40℃。明胶作为银杏叶提取液的除杂澄清剂稳定、可行。In this study,the content of flavonol glycosides was used as an evaluation index to screen the six kinds of clarifying agent,including diatomite,gelatin,chitosan,101 juice clarifying agent,ZTC1 ＋ 1 natural clarifier and activated carbon,single factor and orthogonal test were applied to optimize the clarifying condition of Ginkgo biloba extract. The results showed the optimal clarification condition of G. biloba extract were： gelatin as the clarifying agent,3 m L per 10 g crude drugs with 1% gelatin solution,6∶ 1（ m L / g） as extraction concentration,5. 5 as extraction p H,40 ℃ as extraction temperature. Gelatin can be used as a clarifying agent of G. biloba extract and it is stable and feasible.

关 键 词：壳聚糖 硅藻土 明胶 101果汁澄清剂 ZTC1+1天然澄清剂 活性炭絮凝澄清剂 银杏叶 

分 类 号：R944.9[医药卫生—药剂学]