pH敏感聚合物胶束给药系统的研究进展  

Recent progress in research of pH-sensitive polymeric micelles as drug delivery system

作　　者：王狄狮 周艳霞[1] 李承洧 屈小又 王子琪[1] 李馨儒[1] 易崇勤 刘艳[1] 

机构地区：[1]北京大学药学院分子药剂学与新释药系统北京市重点实验室,北京100191 [2]方正医药研究院有限公司,北京102206

出　　处：《中国新药杂志》2016年第19期2218-2224,共7页Chinese Journal of New Drugs

摘　　要：pH敏感聚合物胶束以其粒径小、载药量高、可控释药等优势近年来受到广泛关注,特别对于抗肿瘤药物的靶向递送来说,p H敏感聚合物胶束呈现出极大的应用潜力。本文主要从p H敏感聚合物胶束作为药物载体的理论基础、类型和p H敏感机制等方面综述了p H敏感聚合物胶束纳米给药系统的研究进展。pH-sensitive polymeric micelles have received increasingly intensive attention due to their considerable advantages such as small particle size,high drug loading,and controlled release. They have exhibited huge potential of application in the targeted delivery of anticancer drugs. This review highlights recent progress of p H-sensitive polymeric micelles as drug carriers in respects of the theoretical basis,types,and p H-sensitivity mechanisms.

关 键 词：pH敏感聚合物胶束 给药系统 pH敏感性机制 纳米递药系统 超分子聚合物 大分子自组装 

分 类 号：R944.9[医药卫生—药剂学]