盐酸羟考酮注射液用于甲状腺手术患者全麻诱导的临床观察  

Preliminary observation of oxycodone hydrochloride injection for general anesthesia induction in patients undergoing thyroid surgery

作　　者：姚月勤[1] 范志毅[1] 刘英华[1] 陈冀衡[1] 

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所,恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142

出　　处：《中国新药杂志》2016年第19期2225-2228,共4页Chinese Journal of New Drugs

摘　　要：目的：通过对甲状腺手术患者使用芬太尼和盐酸羟考酮注射液联合丙泊酚全麻诱导,探讨羟考酮注射液用于短小手术全麻诱导的可行性。方法：选择ASAⅠ-Ⅱ级、择期全麻下行甲状腺手术患者60例,随机分为3组（n=20）。3组分别给予芬太尼2μg·kg^-1（F组）、羟考酮0.1 mg·kg^-1（Q1组）或羟考酮0.2 mg·kg^-1（Q2组）联合丙泊酚2 mg·kg^-1和顺阿曲库铵0.2 mg·kg^-1进行全麻诱导。观察3组患者的入室基础值（T0）、喉镜暴露前（T1）、气管插管即刻后（T2）和插管后1 min（T3）的收缩压（SBP）、舒张压（DBP）、平均压（MAP）、心率（HR）、脑电双频指数（BIS）以及术后苏醒时间和拔管时间。结果：3组各时间点的血压、心率和BIS值均无显著性差异。但在T2时刻,F组血压比T0有所升高;Q1组SBP比T0低;Q2组血压比T0低,其中SBP下降有显著性差异（P〈0.05）。术后苏醒时间和拔管时间无显著差异;术后恶心呕吐发生率无显著差异。结论：羟考酮注射液0.2 mg·kg^-1联合丙泊芬2 mg·kg^-1能提供很好的插管条件,并能较充分地抑制心血管反应,且不影响患者苏醒;可以用于短小手术的全麻诱导。Objective： To explore the feasibility of using oxycodone injection in combination with propofol for short anesthesia induction for thyroid surgery. Methods： Sixty patients of ASAⅠ - Ⅱ grade to receive elective thyroid surgery under general anesthesia were randomly divided into three groups,with 20 in each group. Induction of anesthesia in the three groups were conducted by intravenous injection of fentanyl 2 μg·kg^-1（ F group）,oxycodone 0. 1 mg·kg^-1（ Q1 group）,oxycodone 0. 2 mg·kg^-1combined with propofol 2 mg·kg^-1and cis-atracurium0. 2 mg·kg^-1（ Q2 group）,respectively. Systolic blood pressure（ SBP）,diastolic blood pressure（ DBP）,mean pressure（ MAP）,heart rate（ HR）,and bispectral index（ BIS） were recorded at entrance（ T0）,before intubation（ T1）,after intubation（ T2）,and 1 min after intubation（ T3）. Postoperative awake time and extubation time were recorded,too. Results： There was no significant difference among the three groups at each time point in the blood pressure,HR,and BIS. At T2,F group had the largest increase in blood pressure which was slightly higher than the baseline value,while the blood pressure in Q2 group was lower than that at T0,and SBP was significantly decreased（ P〈0. 05）. Postoperative awake time,extubation time,and the incidence of postoperative nausea and vomiting did not show significant difference. Conclusion： Oxycodone injection of 0. 2 mg·kg^-1combined with propofol of 2 mg·kg^-1can provide good intubating conditions and more fully suppress cardiovascular reactions,and it does not affect the patients＇ revival,thus can be used for anesthesia induction of short surgeries.

关 键 词：盐酸羟考酮注射液 全麻诱导 甲状腺手术 

分 类 号：R971.2[医药卫生—药品]