胶原蛋白在三维生物打印中的应用研究进展  

Advances in the research of application of collagen in threedimensional bioprinting

作　　者：李海航[1] 罗鹏飞[1] 盛嘉隽 刘功成[1] 朱世辉[1] 

机构地区：[1]第二军医大学长海医院烧伤外科,全军烧伤研究所,上海200433

出　　处：《中华烧伤杂志》2016年第10期638-640,共3页Chinese Journal of Burns

摘　　要：三维生物打印技术具有精度高、可控性强的特性，在医疗临床和实验领域更是发展迅速。而胶原蛋白广泛存在于动物的皮肤、骨、肌腱等组织中，是具有良好生物学特性的材料，尤其在组织工程领域中应用广泛。目前，三维生物打印研究常常需要应用胶原蛋白作为其生物“墨水”主要成分，为此，笔者做一综述阐述目前胶原蛋白在二三维生物打印中的应用研究进展。As a new industrial technology with characteristics of high precision and accuracy, the application of threedimensional bioprinting technology is increasingly wide in the field of medical research. Collagen is one of the most common ingredients in tissue, and it has good biological material proper ties. There are many reports of using collagen as main composition of ＂ink＂ of three-dimensional bioprinting technology. How- ever, the applied collagen is mainly from heterogeneous sources, which may cause some problems in application. Recombinant human source collagen can be obtained from microorganism fer- mentation by transgenic technology, but more research should be done to confirm its property. This article reviews the advances in the research of collagen and its biological application in three-di- mensional bioprinting.

关 键 词：胶原 组织工程 三维生物打印 

分 类 号：R318.08[医药卫生—生物医学工程] TP391.73[医药卫生—基础医学]