异基因造血干细胞移植后B淋巴细胞重建及其影响因素  

B lymphocyte reconstitution and its influencing factors after allogeneic hematopoietic cell transplantation

作　　者：刘会兰[1] 孙自敏[1] 

机构地区：[1]安徽医科大学附属安徽省立医院血液科,合肥230001

出　　处：《国际输血及血液学杂志》2016年第5期399-404,共6页International Journal of Blood Transfusion and Hematology

基　　金：安徽省科技厅科技计划项目（1301043028）;安徽省卫生计生委医学科研计划项目（13zc018）

摘　　要：异基因造血干细胞移植（allo—HSCT）后患者的免疫重建与其移植结果密切相关。移植后B淋巴细胞重建是allo—HSCT后患者机体主动免疫重建的重要组成部分。移植物来源及组成、预处理方案、移植物抗宿主病（GVHD）的发生及其治疗均可影响allo—HSCT后患者的B淋巴细胞重建，而allo—HSCT后B淋巴细胞及其亚群的快速重建可降低GVHD的发生率。笔者就影响allo—HSCT后B淋巴细胞重建的因素及B淋巴细胞重建对移植结果的影响作一综述。The clinical outcome after allogeneic hematopoietic stem cell transplantation （allo-HSCT） is closely related to the status of immune reconstitution. B lymphocyte reconstitution is one of the main part of the active immune reconstitution after allo-HSCT. The source and component of graft, conditioning regimen, graft-versus-host disease（GVHD） and its treatment are main factors affecting B lymphocyte reconstitution. On the other hand, rapid B lymphocyte reconstitution after allo-HSCT can reduce the occurrence of GVHD. Here the authors review B lymphocyte reconstitution and its influencing factors after allo-HSCT.

关 键 词：B淋巴细胞 免疫 功能恢复 移植 

分 类 号：R457.7[医药卫生—治疗学]