不规则抗体在临床输血治疗中的研究进展  

Research progress of irregular antibodies in clinical blood transfusion

作　　者：张曼[1] 魏春梅[2] 杨尖措[2] 

机构地区：[1]青海大学,西宁810000 [2]青海红十字医院,西宁810000

出　　处：《国际输血及血液学杂志》2016年第5期448-451,共4页International Journal of Blood Transfusion and Hematology

摘　　要：不规则抗体是指血清中除抗-A、-B、-AB以外所有血型抗体的总称。目前大量研究表明，不规则抗体是引起溶血性输血反应（HTR）、新生儿溶血病（HDN）、同种免疫性血小板减少症（AIT）、血型鉴定困难及疑难配血等的主要原因之一。因此，笔者拟从不规则抗体的种类及其特点，不规则抗体与相关性疾病的关系，已检出不规则抗体患者的输血策略，以及对不规则抗体的临床管理建议这4个方面进行综述，旨在为该类患者的临床输血治疗及交叉配血提供理论依据。Irregular antibodies include all antibodies other than anti-A,-B,-AB in serum. Currently, numbers of studies have shown that the irregular antibodies are one of the main reasons that cause immune hemolytic transfusion reaction （HTR）, hemolytic disease of the newborn （HDN）, alloimmune thrombocytopenia （AIT）, the difficult cross identification of clinical blood type, difficult crossmatching of blood and so on. Therefore, we review the types and characters of irregular antibodies, relationship between clinical diseases and irregular antibodies, the transfusion strategy of patients with irregular antibodies, and the recommendations for irregular antibodies management, in order to provide a theoretical basis for clinical blood transfusion and crossmatching.

关 键 词：输血 溶血 血小板减少 抗体特异性 不规则抗体 

分 类 号：R457.1[医药卫生—治疗学]