单分散海藻酸钙凝胶微球的制备及其缓释研究  

Preparation of Monodisperse Calcium Alginate Gel Micro-spheres and Its Applications in Controlled Release Studies

作　　者：顾晓龙[1] 蒋建国[1] 张睿[1] 

机构地区：[1]扬州职业大学生物与化工工程学院,江苏扬州225009

出　　处：《广州化工》2016年第19期120-122,125,共4页GuangZhou Chemical Industry

摘　　要：利用表面张力和重力的平衡,采用悬滴-凝胶化法制备了均一的、直径在1 mm左右海藻酸钙微球颗粒。采用紫外-可见光谱分析法对一种模型分子(甲基绿)在该微球中的缓释过程进行了研究,并建立了扩散传质的数学模型。粒径的均一性使该模型只需要针对单个微球而设立,并具有严格的分析解,由此我们计算出了该分子在海藻酸钙凝胶微球中的扩散系数D。这一研究对药物控缓释动力学的研究具有借鉴意义。By balancing surface tension and gravity forces, monodisperse calcium alginate gel micro-spheres with sizes of about 1 mm were prepared through a dropping-gelation method. Brilliant green, a model drug molecule, was used to study the controlled release process inside the micro-spheres through UV- vis measurements, and a mass diffusion model was developed. The monodispersity made it possible to represent the whole system with a model only targeting one single micro-sphere, and a strict analytical solution was derived. Based on this model, the diffusion coefficient D of this molecule in alginate gel was calculated. The method gave new implications in field of controlled drug release kinetic studies.

关 键 词：海藻酸钙微球 药物缓释 紫外-可见光谱 扩散系数 

分 类 号：O643.11[理学—物理化学]