基于火焰原子吸收光谱法的苯甲酸阿格列汀中残留钯测定  

Determination of Residual Palladium in Alogliptin Benzoate by Flame Atomic Absorption Spectrometry

作　　者：谢贞建[1] 袁海梅[1] 孙敏[1] 彭聪[1] 邹亮[2] 

机构地区：[1]成都大学药学与生物工程学院,四川成都610106 [2]成都大学医学院,四川成都610106

出　　处：《成都大学学报（自然科学版）》2016年第3期215-217,共3页Journal of Chengdu University（Natural Science Edition）

基　　金：四川省科技厅成果转化分析测试服务计划(12CGPT0022-16)资助项目

摘　　要：建立了一种基于火焰原子吸收光谱法测定残留钯的方法：苯甲酸阿格列汀原料药经前处理后,直接用火焰原子吸收光谱法进行测定.结果显示,残留钯元素的标准曲线线性范围在0~1.6μg/m L,相关系数为0.9997,方法回收率在94.8%~104.6%之间,检出限为0.03μg/m L,重复性RSD=3.45%（n=5）.方法操作简便、迅速,有较好的准确度与精密度,可适用于苯甲酸阿格列汀中残留钯的测定.The paper is going to establish a method for the determination of residual palladium in Alogliptin Benzoate by flame atomic absorption spectrometry（FAAS）. Residual palladium in Alogliptin Benzoate is di- rectly determined by FAAS after the pre-treatment of the raw material of Alogliptin Benzoatin. The results show that the linear range was from 0 to 1.6μg/mL, while the relevant coefficient is 0.9997. The method recovery is 94.8 % - 104.6 %, the detection limit of the method is 0.03 μg/mL, and the repeatability of the method is RSD = 3.45% （n = 5）. The conclusion drawn from the experiment shows that this method is sim- ple, rapid, accurate, and precise; therefore, it can be applied in the determination of residual palladium in Alogliptin Benzoate.

关 键 词：火焰原子吸收光谱法 苯甲酸阿格列汀 钯 

分 类 号：R927.2[医药卫生—药学] O657.31[理学—分析化学]