病毒性肝炎临床检测指标的诊断分析  

Diagnosis and analysis of clinical detection indexes of viral hepatitis

作　　者：徐凤玲[1] 吕江峰[2] 庄伟[2] 王慧[3] 周薇[1] 

机构地区：[1]莱芜市人民医院输血科,山东莱芜271199 [2]莱芜市人民医院检验科,山东莱芜271199 [3]莱芜市人民医院供应室,山东莱芜271199

出　　处：《中华医院感染学杂志》2016年第19期4362-4364,共3页Chinese Journal of Nosocomiology

基　　金：山东省自然科学基金资助项目(2014RAD189)

摘　　要：目的分析联合检测外周血丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰基转移酶(GGT)对各类肝脏疾病的临床诊断价值,为肝脏疾病的鉴别诊断提供参考依据。方法选取医院2012年6月-2015年6月收治184例肝脏疾病患者为研究组,并选取同期50例健康体检者为对照组,比较两组受试者外周血ALT、AST、GGT等指标水平,并观察各类肝脏疾病患者ALT、AST、GGT阳性率的差异。结果急性病毒性肝炎、重型病毒性肝炎患者,外周血ALT、AST、GGT水平显著高于对照组,肝炎性肝硬化、原发性肝癌患者,外周血AST、GGT水平显著高于对照组,差异有统计学意义(P<0.05);两组受试者外周血ALT、AST、GGT阳性率差异与其表达水平差异一致,原发性肝癌患者PT、APTT、TT均显著高于对照组,肝炎性肝硬化患者APTT、TT均显著高于对照组,肝脏疾病患者FIB水平均显著低于对照组,差异有统计学意义(P<0.05)。结论联合检测外周血ALT、AST、GGT及FIB水平,有助于为各类肝脏疾病的临床鉴别诊断提供可靠的实验室数据,诊断价值良好。OBJECTIVE To analyze clinical diagnosis value of the combined detection to peripheral blood alanine aminotransferase（ALT）,aspartate aminotransferase（AST）and gammaglutamyltransferase（GGT）on various types of liver disease,so as to provide reference for identification and diagnosis to liver disease.METHODS A total of 184 patients with liver disease admitted in our hospital from Jun.2012 to Jun.2015 were selected as research group,and 50 cases of healthy physical examinees in the same period were enrolled in the control group.The levels of peripheral blood ALT,AST and GGT were compared between the two groups,and the difference of positive rates of ALT,AST and GGT were observed in all kinds of liver disease patients.RESULTS The levels of ALT AST and GGT in patients with acute viral hepatitis and severe viral hepatitis were significantly higher than those in control group.The levels of GGT and AST in peripheral blood in patients with hepatitis cirrhosis and primary hepatic carcinoma were significantly higher than those in control group（P〈0.05）.The positive rates of GGT,AST and ALT in the peripheral blood of each group were consistent with the difference of the expression level.APTT,TT and PT in patients with primary liver cancer were significantly higher than those in the control group;The APTT and TT in patients with hepatitis cirrhosis were significantly higher than those in the control group;FIB in patients with liver disease was significantly lower than that in the control group（P〈0.05）.CONCLUSION The combined detection of FIB,GGT,AST and ALT levels in peripheral blood could help to provide reliable laboratory data for clinical identification and diagnosis of liver diseases with good diagnosis value.

关 键 词：丙氨酸氨基转移酶 天门冬氨酸氨基转移酶 谷氨酰基转移酶 肝脏疾病 诊断 

分 类 号：R512.6[医药卫生—内科学]