亚低温和川芎嗪对新生儿缺氧缺血性脑病的保护作用  

Neuroprotective Effect of Mild Hypothermia and Ligustrazine on Neonatal Hypoxic-Ischemic Encephalopathy

作　　者：魏丽夏[1] 任青[1] 赵淑云[1] 张勇军[1] 

机构地区：[1]山东省聊城市人民医院,山东聊城252000

出　　处：《儿科药学杂志》2016年第10期12-15,共4页Journal of Pediatric Pharmacy

摘　　要：目的:通过测定亚低温和川芎嗪治疗新生儿缺氧缺血性脑病(HIE)血清神经元特异性稀醇化酶(NSE)水平及其行为神经评分(20项NBNA评分),研究亚低温和川芎嗪对新生儿HIE的保护作用。方法:将80例中重度HIE患儿随机分为4组:亚低温治疗组、川芎嗪治疗组、亚低温联合川芎嗪治疗组(联合治疗组)和常规对照组,另取10例正常新生儿作为正常对照组。入选新生儿于生后24 h、3 d、7 d检测血清NSE水平,生后3 d、7 d、14 d进行行为神经测定。结果:常规对照组各时间点NSE水平较亚低温治疗组、川芎嗪治疗组及联合治疗组表达增加,差异有统计学意义(P<0.01);常规对照组各时间点NBNA评分均较亚低温治疗组、川芎嗪治疗组和联合治疗组减少,差异有统计学意义(P<0.01)。结论:亚低温和川芎嗪对新生儿HIE有保护作用。Objective： To explore the neuroprotective effect of mild hypothermia and ligustrazine on neonatal hypoxic-ischemic encephalopathy （HIE） in newborn and explore its effect on serum neuron specific enolase （NSE） levels and behavioral neurological assessment. Methods： Eighty infants with moderate to severe HIE were randomly divided into four groups： mild hypothermia treatment group, ligustrazine treatment group, mild temperature and ligustrazine treatment group （combination group） and conventional control group, another 10 cases of normal newborns selected as normal control group. The serum NSE at the age of 24 hours, 3 days and 7 days after birth, and NBNA scores at the age of 3, 7, 14 days after birth were dynamic monitored. Results： The NSE levels of mild hypothermia treatment group, ligustrazine treatment group, combination group were decreased than those of conventional control group at all points （P〈0. 01 ）. The NBNA scores of conventional treatment group at all points were less than the three treatment groups （P〈 0. 01 ）. Conclusion： Mild hypothermia and ligustrazine have protective effect on neonatal hypoxic-ischemic encephalopathy.

关 键 词：亚低温 川芎嗪 缺氧缺血性脑病 神经元特异性稀醇化酶 行为神经测定 

分 类 号：R725.1[医药卫生—儿科]