丹芍汤佐治小儿过敏性紫癜肾炎疗效观察  

Clinical Effect of Danshao Decoction in Children with Henoch-Schnlein Purpura Nephritis

作　　者：徐铁华 

机构地区：[1]浙江省兰溪市人民医院,浙江兰溪321100

出　　处：《儿科药学杂志》2016年第10期21-23,共3页Journal of Pediatric Pharmacy

摘　　要：目的:探讨丹芍汤辅助常规疗法治疗小儿过敏性紫癜肾炎(HSPN)的效果,为其临床应用提供参考。方法:采用前瞻性研究方法,将103例HSPN患儿随机分为对照组51例和观察组52例,对照组采用常规综合治疗(醋酸泼尼松片、雷公藤多苷片、双嘧达莫片、维生素C片),观察组在常规综合治疗基础上加用丹芍汤口服(每日早晚各一次),治疗8周(2个疗程)。观察并比较两组患儿的中医证候评分、临床疗效及实验室指标。进一步对观察组进行中医证型分型,观察不同中医证型的治疗效果。结果:治疗前,两组患儿中医证候评分比较差异无统计学意义(P>0.05);治疗后4周、6周、8周,观察组的中医证候评分均低于对照组(P均<0.01);治疗8周,观察组临床疗效优于对照组,24 h尿白蛋白水平和尿红细胞计数低于对照组(P均<0.05)。治疗8周,观察组不同中医证型之间临床疗效比较差异无统计学意义(P>0.05),但中医证候评分、尿红细胞计数比较差异有统计学意义(P<0.05)。结论:丹芍汤辅助治疗HSPN疗效可靠,但在各中医证型中的差异性还有待进一步研究。Objective： To explore the effect of Danshao decoction in the treatment of children with Henoch-Schsnlein purpura nephritis （HSPN）, so as to provide basis for its clinical use. Methods： One hundred and three HSPN children were divided into two groups in a prospective study, and 51 patients in the control group were treated with traditional methods, while 52 patients in the observation groups were given Danshao decoction at the same time. The Traditional Chinese Medicine （TCM） symptom score, clinical effect and laboratory index were compared between two groups. Further more, children in the observation group were divided into 4 groups according to TCM syndrome-type, and the effects were compared between each group. Results： Before treatment, there was no significant difference between two groups in TCM symptom score, 4 weeks, 6 weeks and 8 weeks after treatment, the TCM symptom scores of observation group were lower than the control group （P〈0.05）. Eight weeks after treatment, the clinical effective rate of observation group was higher than that of the control group, 24 hours urine albumin level and urinary RBC count were both lower than those of the control group, and the differences had statistical significance （P〈0. 05 ）. The clinical effective rate between different TCM syndrome-types had no significant difference, but the differences in the TCM symptom scores and the urinary RBC counts had statistical significance （P〈 0. 05）. Conclusion： Danshao decoction can get reliable curative effect in the treatment of HSPN, but the differences between different TCM syndrome-types need further research.

关 键 词：过敏性紫癜肾炎 丹芍汤 中医药 中医证型 

分 类 号：R725.9[医药卫生—儿科]