血清尿酸水平与男性心房颤动患病率的相关性研究  

THE ASSOCIATION OF SERUM URIC ACID LEVELS AND THE PREVALENCE OF MALE ATRIAL FIBRILLATION

作　　者：马丽梅[1] 关凤焕[2] 吴寿岭[3] 杨方[4] 金成[3] 刘业强[5] 邢爱君[3] 

机构地区：[1]河北省唐山市协和医院心内科,063000 [2]开滦总医院CT室 [3]开滦总医院心内科 [4]华北理工大学医学实验中心 [5]开滦总医院内分泌科

出　　处：《中国煤炭工业医学杂志》2016年第10期1428-1431,共4页Chinese Journal of Coal Industry Medicine

基　　金：唐山市科学技术研究与发展指导计划项目(编号:13130228b)

摘　　要：目的探讨男性血清尿酸水平与心房颤动患病率的相关性。方法根据对80 006名男性的调查资料,将调查对象依据血清尿酸水平四分位,用Logistic回归分析血清尿酸水平与房颤患病率的相关性,得出在校正了已知房颤相关危险因素后的OR(odds ratio)值。结果在被调查的人群中,血清尿酸四分位心房颤动的患病率分别是0.21%、0.33%、0.58%和0.86%,在校正了年龄、收缩压(SBP)、舒张压(DBP)、体质指数(BMI)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)和C-反应蛋白(hs-CRP)、吸烟、饮酒和相关疾病史之后,四分位中第2、3、4分位的OR值分别比第1分位的增高1.61、2.78、3.41倍。结论高血清尿酸水平人群的心房纤颤患病率较高,高血清尿酸水平与心房纤颤独立相关。Objective To survey the association of serum uric acid （SUA） and the prevalence atrial iibrillation （AF） in Chinese male population. Methods We evaluated 80,006 male participants. They were classified into quartiles according to SUA level. Data were analyzed to examine the association between SUA levels and the prevalence of AF. A logistic regression models was used to estimate the odds ratio （OR） of AF after adjusting for known risk faetors. Results In the surveyed population, the rate of prevalence of AF for the four quartiles of SUA was 0. 21%, 0.33%, 0. 58%, and 0. 86%, respectively. After adjusting for age, SBP, DBP, BMI, TG,TC, HDL-C, LDL-C, FBG, CRP, smoking, alcohol drinkingl and medical history, the OR of quartiles of higher SUA was 1.61, 2.78, or 3.41 folds higher than that of the first quartile. Conclusion The population with high SUA has higher prevalence of AF. High level of SUA is independently associated with AF.

关 键 词：血清尿酸 心房纤颤 风险因子 患病率 横断面研究 

分 类 号：R541.75[医药卫生—心血管疾病]