六元氮杂环卡宾前体催化剂的合成  

Synthesis of Chiral 6-Membered Ring N-Heterocyclic Carbene Precursor Catalysts

作　　者：何成祥 黄立梁[1] 张泽东[1] 孙智华[1] 

机构地区：[1]上海工程技术大学化学化工学院,上海201620

出　　处：《化学试剂》2016年第10期1003-1007,共5页Chemical Reagents

基　　金：上海市科委资助项目(12430501300)

摘　　要：以中间体2-(氨基(苯基)次甲基)苯胺和芳基硼酸类化合物为原料,经过Chan-Lam偶联反应,区域选择性地得到中间化合物。再在钯催化条件下,将前一步的中间化合物与含强供电子基团或强吸电子基团的卤代物进行反应,顺利地得到碳氮键偶联产物。之后经过关环,得到两类电性不同的手性六元氮杂环卡宾前体,其结构经~1HNMR、^(13)CNMR、HRMS进行表征,总收率为39%。Applying Chan-Lam coupling condition,the target compounds were synthesized from the region-selective coupling reac- tion of 2-（ amino（phenyl） methyl）benzenamine and aryl boronic acids. Next, C--N bond coupling products were obtained success- fully under the condition of Pd catalyst. The chiral 6-membered ring N-heterocyclic carbene precursors were eventually afforded by cyelization reaction. The structure of the new compounds were confirmed by 1HNMR, 13 CNMR and HRMS. The overall yield was 39%.

关 键 词：偶联反应 钯催化 合成 卡宾前体 扩环 

分 类 号：O625.63[理学—有机化学]