雌激素受体α在IgA肾病肾组织中的表达及其意义  

Expression and significance of estrogen receptor alpha in renal tissue of IgA nephropathy

作　　者：于文娟[1] 赵蓓[1] 钟海珍[1] 姚刚[1] 

机构地区：[1]南京医科大学第二附属医院肾脏科,南京210011

出　　处：《中国医师杂志》2016年第9期1316-1319,共4页Journal of Chinese Physician

摘　　要：目的探讨免疫球蛋白A（IgA）肾病肾组织中雌激素受体α（ERα）的表达及意义。方法收集肾组织标本50例，其中IgA肾病45例，正常肾组织5例，采用免疫组化法检测ERα的表达，分析其与相关临床参数、肾小球损害程度的关系。结果ERα在IgA肾病和正常肾组织肾小球和肾小管均有表达，随着病变程度的加重，IgA肾病肾组织肾小球内ERα的表达逐渐减弱（P＝0.001），且其表达与肾小球滤过（eGFR）、血肌酐（Scr）、IgA肾病的病理分级相关（r＝0.876、－0.818、－0.736，P〈0.05）；与非高血压组比较，IgA肾病高血压组肾小球内ERα的表达明显减少，差异有统计学意义（P＝0.011）。结论ERα在IgA肾病肾组织肾小球内的表达明显减少，并与肾损害程度相关，提示ERα可能在IgA肾病的发展过程中起一定作用。ObjectiveTo investigate the expression and significance of estrogen receptor alpha in renal tissue of immunoglobulin A （IgA） nephropathy.MethodsFifty renal tissue samples including forty five cases of IgA nephropathy and five cases of normal expression were collected. The expression of estrogen receptor α （ERα） was detected by immunohistochemistry method, and its relationship with clinical parameters and the degree of glomerular damage were analyzed.ResultsERα was located in the glomerular and renal tubules. With the severity of the lesion, the expression of ERα in renal tissue of IgA nephropathy decreased gradually （P=0.001） and its expression was associated with estimated glomerular filtration rate （eGFR）, serum creatinine （Scr）, and pathologic grade of IgA nephropathy （r=0.876, -0.818, and -0.736, P〈0.05）, The expression of ERα was significantly decreased in hypertensive patients with IgA nephropathy, and the difference was statistically significant compared with that in non-hypertensive group （P=0.011）.ConclusionsThe expression of ERα in renal tissue of IgA nephropathy was significantly decreased and there was a correlation between the degree of renal tissue damage, suggesting that ERα might play a role in the development of renal disease.

关 键 词：雌激素受体α/代谢 肾小球肾炎 免疫球蛋白A/代谢 

分 类 号：R692.31[医药卫生—泌尿科学]