萆薢渗湿汤加味对假丝酵母菌病患者阴道免疫状态的影响  

Effects of modified Bixie Shenshi Decoction on the vaginal immune status of vulvovaginal candidiasis patients

作　　者：郑文兰[1] 徐超[1] 杨江燕[1] 

机构地区：[1]贵阳中医学院第一附属医院妇科,贵阳550001

出　　处：《中华中医药杂志》2016年第10期4338-4340,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：贵州省科学技术基金项目(No.20122079)~~

摘　　要：目的:探讨萆薢渗湿汤加味对假丝酵母菌病(VVC)患者阴道免疫状态的影响。方法:将90例VVC患者随机分为A、B、C3组,另选取15名健康无阴道炎者作D组。A组:制霉菌素阴道上药;B组:萆薢渗湿汤加味口服兼熏洗;C组:B组治疗同时加制霉菌素外用;D组:无治疗。取受试者阴道灌洗液作白细胞介素-2(IL-2)、白细胞介素-6(IL-6)检测。结果:A、B、C组的治愈率、总有效率分别为66.67%、90%,16.7%、73.3%,93.3%、90.6%;复发率为35.00%、40.00%、3.57%。治疗前VVC患者阴道灌洗液中IL-2浓度较D组低(P<0.05),IL-6较D组高(P<0.05);治疗后IL-2浓度较治疗前升高(P<0.05);IL-6降低(P<0.05),C组尤为明显(P<0.05)。结论:萆薢渗湿汤加味联合制霉菌素治疗VVC疗效好、复发率低。VVC的发病可能与IL-2下降及IL-6升高有关。Objective： To study the effect of modified Bixie Shenshi Decoction on vulvovaginal candidiasis（VVC） patients＇ vaginal immune status. Methods： Ninty VVC patients were randomly divided into group A, B and C, and another 15 healthy women were collected as group D. Group A was treated by nystatin tablets which was applied to vagina; group B was given oral administration, fumigation and washing of modified Bixie Shenshi Decoction; group C was treated with combined method of group A and group B; group D was not receiving any treatment. Vaginal lavage fluid of the subjects was taken to conduct IL-2, IL-6 examinations. Results： The cure rate and total effective rate of three groups were 66.67%, 90%（group A）, 16.7%, 73.3%（group B）, 93.3%, 100%（group C）, respectively. The recurrence rates of three groups were 35.00%, 40.00% and 3.57%. Before treatment, the IL-2 of VVC patients was lower than group D（P〈0.05）, and IL-6 was higher than Group D（P〈0.05）. After treatment, the IL-2 of three groups increased（P〈0.05）, and the IL-6 decreased（P〈0.05）. Group C changed significantly（P〈0.05）. Conclusion： Modified Bixie Shenshi Decoction combined with Nystatin Tablets in treating VVC has a great curative effect with low recurrence rate. The pathogenesis of VVC patients might be related to the decrease of IL-2 and the increase of IL-6.

关 键 词：萆薢渗湿汤 制霉菌素片 假丝酵母菌病 白细胞介素 带下病 湿热下注 阴道炎 

分 类 号：R285.6[医药卫生—中药学]