贝美前列素治疗眼球钝挫伤后继发性青光眼11例  

Effect of Ocular Hypotensive Action of Bimatoprost in 11 Cases of Patients with Glaucoma or Ocular Hypertension Following Contusion

作　　者：马雅[1] 徐玲娟[1] 杨红[1] 侯小龙[2] 胡军[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院眼科,武汉430030 [2]华中科技大学同济医学院附属同济医院药学部,武汉430030

出　　处：《医药导报》2016年第10期1086-1089,共4页Herald of Medicine

摘　　要：目的 观察贝美前列素治疗眼球钝挫伤后继发性青光眼的疗效,并探讨其作用机制。方法 回顾性分析 2014 年 9月—2016 年5 月间收治住院11例患者11只眼球钝挫伤后继发性青光眼,经贝美前列素联合其他治疗后眼压控制情况。结果 11例患者中9例眼压降至正常,眼压降幅1.995~5.985 kPa,平均4.243 kPa。2例经药物及常规治疗后眼压仍不能稳定于正常范围内,其中1例行睫状体光凝术后眼压降至正常范围,1例行后段玻璃体切割术后联合用药,眼压降至正常范围。结论 贝美前列素能显著降低眼球钝挫伤后继发性青光眼患者的眼压,且能在其他抗青光眼药物降压效果不佳时发挥良好的降眼压作用。Objective To observe the effect of ocular hypotensive action of bimatoprost in patients with glaucoma following contusion,and discuss the possible mechanism. Methods Eleven patients with glaucoma following contusion were treated with bimatoprost and other regular medications or surgeries during Sep.2014 to May 2016.The intraocular pressure （IOP） was retrospectively observed. Results In these eleven cases,nine achieved normal IOP,by reducing 1.995-5.985 kPa and 4.243 kPa on average,while the other two failed.One finally achieve the IOP reduction after transscleralcyclophotocoagulation,the other made it after vitrectomy. Conclusion Bimatoprost can significantly reduce the IOP of patients with glaucoma following contusion,especially when other antiglaucoma drugs failed to maintain the IOP in the target range.

关 键 词：贝美前列素 钝挫伤 眼球 青光眼 继发性 外伤 

分 类 号：R971.9[医药卫生—药品] R775.3[医药卫生—药学]