应激时中枢性胰高血糖素样肽1对下丘脑-垂体-肾上腺轴作用的研究进展  

Research Progress in the Effect of Central Glucagon-like Peptide-1 on Hypothalamic-pituitary-adrenal Axis in Stress

作　　者：韩闻卿 姜雅秋[1] 

机构地区：[1]中国医科大学附属第一医院内分泌与代谢病科内分泌研究所与辽宁省内分泌疾病重点实验室,沈阳110001

出　　处：《医学综述》2016年第19期3753-3756,共4页Medical Recapitulate

基　　金：辽宁省科学技术计划项目(2012225021)

摘　　要：胰高血糖素样肽1(GLP-1)在神经元中表达,在应激中对下丘脑-垂体-肾上腺(HPA)轴有重要调节作用。在大脑,GLP-1主要产生于尾部孤束核和后脑腹外侧髓质,其反应纤维直接支配室旁核调节垂体功能的促肾上腺皮质激素释放激素(CRH)神经元。中枢性给予GLP-1激活HPA轴的反应可被GLP-1受体拮抗剂阻断,因此GLP-1在糖皮质激素分泌中具有兴奋作用。外源或内源性糖皮质激素可降低胰高血糖素原(PPG)信使RNA和GLP-1的生物利用度,表明存在一种反馈机制可限制应激引发的HPA轴过度反应。Glueagon-like peptide-1 （ GLP-1 ） expression exists in the neurons and plays an important regulating role on the hypothalamic-pituitary-adrenal （HPA） axis in the stress response. In the brain, the main production site of GLP-1 is caudal nucleus of the solitary tract and the ventrolateral medulla of the afterbrain. Its immunoreactive fibers control the corticotropin-releasing hormone （CRH） neurons directly,which distrib- ute in the hypothalamic paraventricular nucleus and regulate pituitary function. The response of HPA axis ac- tivated by central administration of exogenous GLP-1 is blocked by GLP-1 receptor antagonist, demonstrating the excitatory effect of GLP-1 on the secretion of glucocorticoid. Exogenous or endogenous glucocorticoid could reduce the bioavailability of preproglueagon （PPG） mRNA and GLP-1, indicates that there is a feed- back mechanism to restrict overreaction of HPA axis induced by stress stimulation.

关 键 词：胰高血糖素样肽1 应激 下丘脑-垂体-肾上腺轴 室旁核 促肾上腺皮质激素释放激素 

分 类 号：Q577[生物学—生物化学]