组织工程化血管支架材料的研究进展  

Research Progress on Materials of Tissue-Engineered Blood Vessels Scaffolds

作　　者：刘旭倩 王洁[1,2] 

机构地区：[1]河北医科大学口腔医院病理科,石家庄050017 [2]河北省口腔医学重点实验室,石家庄050017

出　　处：《医学综述》2016年第19期3813-3817,共5页Medical Recapitulate

摘　　要：体外组织工程的主要限制是缺乏足够的血管系统,探索组织工程化血管支架材料,为新生血管细胞的生长提供支持和3D生长空间成为构建组织工程化血管研究的关键。组织工程化血管支架材料分为天然生物支架材料,人工合成高分子材料,复合材料和纳米材料等。其中天然生物材料与细胞的相容性强,但存在一定的免疫反应,合成高分子材料生物力学性能好,但与细胞的相容性差。利用纳米技术将多种材料交联,构建混合基质血管支架材料,即血管复合支架材料的研究成为热点。The major limitation of tissue engineering in vitro is lacking of enough vascular system. The key of tissue-engineered blood vessel, scaffold materials, provide supporting and 3 D growth condition for new blood vessels cells. Seaffolds of tissue-engineered blood vessels can be divided into natural biological materials, synthetic polymer materials, composite materials and nano materials. With a certain immune reaction,cells biocompatibility of natural biological material is better than synthetic polymer material. However, with poor cells compatibility, biological mechanics of synthetic polymer material is better than natural biological material. At present, crosslinking several kinds of materials by using nanotechnology to construct vascular composite scaffold materials are becoming more and more popular.

关 键 词：组织工程 血管支架材料 天然生物支架材料 人工合成高分子材料 复合材料 

分 类 号：R318[医药卫生—生物医学工程]