干扰素抗病毒治疗小儿乙肝的临床效果分析  

Clinical Effect Analysis of interferon Antiviral Therapy in Children With Hepatitis B

作　　者：申远方[1] 

机构地区：[1]郑州市儿童医院儿科,河南郑州450000

出　　处：《中国继续医学教育》2016年第27期146-148,共3页China Continuing Medical Education

摘　　要：目的分析干扰素抗病毒治疗小儿乙肝的临床效果。方法选择2014年1月～2015年1月本院收治小儿乙肝104例为研究对象,两组均在服用多磷脂酰胆碱的基础上,对照组采用苦参素,给予观察组干扰素a-2b,分析两组HBV-DNA阴转率及肝功能变化情况。结果在治疗结束1年后HBV-DNA的阴转数7例,阴转率为13.5%;即观察组的阴转率高于对照组,差异有统计学意义（P〈0.05）;观察组的ALT和TBIL低于对照组,差异有统计学意义（P〈0.05）。结论干扰素抗病毒治疗小儿乙肝具显著效果,并且安全性好。Objective To analyze the clinical effect of interferon antiviral therapy in children with hepatitis B. Methods From January 2014 to January 2015, 104 cases of children hepatitis B in our hospital were selected as the research subjects. The two groups were all based on the use of multi phosphatidylcholine, the control group was treated with matrine, and the observation group was treated with interferon a-2b, the changes of HBV-DNA negative conversion rate and liver function in two groups were analyzed. Results 7 cases of Yin speed HBV-DNA after 1 years at the end of treatment, the negative rate was 13.5%. The negative rate of observation group was higher than that of control group, the difference was statistically significant（P〈0.05）. The ALT and TBIL of the observation group were lower than the control group, the difference was statistically significant（P〈0.05）. Conclusion Interferon antiviral treatment of children with hepatitis B has a significant effect, and the security is good.

关 键 词：干扰素 抗病毒 小儿乙肝 临床效果 

分 类 号：R725.1[医药卫生—儿科]