替格瑞洛与氯吡格雷对急性ST段抬高型心肌梗死的临床疗效对比研究  

Comparative Study of the Clinical Efficacy of Carvedilol and Clopidogrel in Acute ST Segment Elevation Myocardial Infarction

作　　者：黄煜[1] 赵灵芳[1] 

机构地区：[1]郑州大学附属洛阳中心医院急诊科,河南洛阳471000

出　　处：《中国继续医学教育》2016年第27期159-161,共3页China Continuing Medical Education

摘　　要：目的对比替格瑞洛与氯吡格雷对急性ST段抬高型心肌梗死的临床疗效。方法选取我院198例急性ST段抬高型心肌梗死患者作为研究对象,分成观察组和对照组,各99例。所有患者均接受阿司匹林治疗,对照组加用氯吡格雷,观察组加用替格瑞洛。结果两组各时间段MACE发生率、不良反应率对比,差异无统计学意义,P>0.05;观察组各时间段血小板计数、ST抬高段回落情况、LVEF高于对照组(P<0.05),其中观察组与对照组治疗后第1周、1个月、6个月时LVEF分别为[(55.11±3.82)%、(59.74±5.25)%、(69.50±6.11)%]、[(48.34±4.60)%、(53.50±4.89)%、(60.83±7.33)%]。结论替格瑞洛与氯吡格雷对急性ST段抬高型心肌梗死的临床疗效接近,均安全可靠。Objective To compare ticagrelor versus clopidogrel in patients with acute ST elevation myocardial infarction clinical curative effect. Methods 198 cases of acute ST segment elevation myocardial infarction in our hospital were selected as the research objects, divided into observation group and control group, each of 99 cases. All patients received aspirin treatment, the control group was treated with clopidogrel, the observation group added with ticagrelor. Results There was no significant difference in incidence of MACE and adverse reaction rate between the two groups in each time period, and the difference was not statistically significant, P〈0.05. In the observation group, the time period of platelet count, ST elevation of the lower part, LVEF higher than the control group（P〈0.05）, the observation group and the control group after treatment of first weeks, 1 months and 6 months respectively LVEF [（55.11±3.82）%,（59.74± 5.25）%,（69.50±6.11）%], [（48.34±4.60）%,（53.50±4.89）%,（60.83±7.33）%]. Conclusion The clinical effect of the treatment of acute ST segment elevation myocardial infarction is close to that of the patients with acute myocardial infarction.

关 键 词：ST段抬高型 替格瑞洛 氯吡格雷 

分 类 号：R9[医药卫生—药学]