SAPHO综合征之湿热致病与肺病及肾病机  

Etiology and Pathogenesis of SAPHO Syndrome: Damp-heat and Secondary Nephropathy after Lung

作　　者：刘东武[1] 李佳[2] 于静[1] 姜兆荣[1] 徐丹[1] 高明利[1] 

机构地区：[1]辽宁中医药大学附属医院风湿病科,辽宁沈阳110032 [2]辽宁中医药大学基础医学院,辽宁沈阳110847

出　　处：《中华中医药学刊》2016年第10期2359-2361,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(81403286)

摘　　要：SAPHO综合征即滑膜炎-痤疮-脓疱病-骨肥厚-骨炎综合征。感染是本病的重要病因,与感染和免疫异常相关。本病发病率低,辨证规律还没有统一认识。(1)先出现掌跖脓疱病皮肤改变后出现骨骼、关节表现的SAPHO综合征辩证求因为湿热袭肺,病机为肺病及肾,此即藏象学说之"母病及子"机理;(2)肺气虚弱是掌跖脓疱病发病的前提,肾精亏虚是疾病传骨及关节的条件;(3)邪气由皮部至络脉至经脉进而累及子脏是SAPHO综合征肺病及肾的路径。SAPHO syndrome stands for synovitis, acne, pustulosis, hyperostosis and osteitis, with a low incidence. The foremost Cause of SAPHO syndrome is an infectious etiology. Bacteria and immunological dysfunction are hypothesized to play a role. There is no uniform understanding of the syndrome differentiation law of SAPHO syndrome. After summarizing four cases ,the author made the following points ： （ 1 ） Damp - heat attacks the lungs, which is the reason of SAPHO syndrome bone and joint symptoms after rash. Osteitis after rash is the performance of secondary nephropathy after lung. So these performance illustrated secondary disease after mother Zang - organ dysfunction. （2） Lung deficiency is the premise of rash onset and essence deficiency is the condition of osteitis. （ 3 ） Cutaneous - collateral - main channels - secondary internal organs is the pathway.

关 键 词：SAPHO综合征 病因病机 湿热 肺病及肾 母病及子 

分 类 号：R25[医药卫生—中医内科学]