动脉粥样硬化易损斑块动物模型的建立  

Establishment of Animal Model of Atherosclerotic Vulnerable Plaque

作　　者：李碧澄 田芳[1] 田野[1] LI Bi-Cheng TIAN Fang and TIAN Ye(Cardiovascular Institute, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China)

机构地区：[1]哈尔滨医科大学附属第一医院心血管内科,黑龙江省哈尔滨市150001

出　　处：《中国动脉硬化杂志》2016年第9期959-962,共4页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金资助项目(81371709)

摘　　要：动脉粥样硬化进展、易损斑块破裂导致主要不良心血管事件发生。易损斑块形成机制和干预措施的研究一直备受瞩目。建立与人体斑块相似的进展性斑块是对易损斑块进行研究的基础及热点。目前,研究者已在多种动物体内建立了多种易损斑块模型。本文对目前建立的易损斑块动物模型进行综述与评价,为完善易损斑块模型的建立提供新思路。The occurrence of major adverse cardiovascular events is the result of advanced atherosclerosis and plaque rupture. The research on the formation mechanism and treatment of vulnerable plaque has been on focus. The basic research and even the hot spot of studying vulnerable plaque is how to produce a progressive plaque like human beings＇. At present,many different vulnerable plaque models have been produced in a variety of animals. In this review,the animal models of vulnerable plaque will be summarized and discussed. And this review may provide new ideas for the production of the vulnerable plaque model.

关 键 词：易损斑块 斑块破裂 动脉粥样硬化 动物模型 

分 类 号：R5[医药卫生—内科学]