高海拔下低氧对高原鼠兔氧解离曲线关键因子的影响  

Effects of hypoxia on the key factors in oxygen dissociation curve of the plateau pika inhabiting high altitude

作　　者：郭凤霞[1,2] 徐晓玲[1,3] 李锦萍[2,4] 曾阳[2,4] 白亚东[4] 

机构地区：[1]浙江大学城市学院,浙江杭州310015 [2]青海师范大学青藏高原环境与资源教育部重点实验室,青海西宁810008 [3]浙江大学药学院,浙江杭州310058 [4]青海师范大学生命与地理科学学院,青海西宁810008

出　　处：《华西药学杂志》2016年第5期475-476,共2页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:81460652;31360068);浙江大学城市学院教师科研基金资助项目(J-15002)

摘　　要：目的研究高海拔下低氧对高原鼠兔氧解离曲线(ODC)关键因子的影响。方法以高原鼠兔为研究对象,模拟2.3、5.0、8.0 km海拔的低氧条件,经连续低氧处理鼠兔14、25 d后,从颈总动脉取血,用血气分析仪测定高原鼠兔的氧分压、血红蛋白的氧饱和度、p H等参数;根据希尔方程计算出n、K、P_(50)值等关键因子,绘制ODC曲线。结果与结论低氧环境下,高原鼠兔的P_(50)值均下降,"S"形ODC曲线左移、中段坡度明显陡峭而延长,可满足机体对氧气的需要。OBJECTIVE To study the effects of hypoxia on the key factors in oxygen dissolution curve （ODC） of the plateau pika inhabiting high altitude. METHODS Plateau pikas were used to study objects in simulated hypoxia conditions respectively at 2.3, 5.0,8. 0 km and the time lasted for 14 d and 25 d. The blood gas analyzer was used to test blood sample collected from common carotid artery （CCA） and measure the O2 partial pressure,the Oz saturation and pH and so on. The n,K and P50 based on Hill equation were worked out and then, the curve of ODC could be drawn. RESULTS and CONCLUSION The result showed that in hypoxia,P50 of plateau pikas was on the downfall, ＂S＂ model of ODC shifted leftward and the middle part of the slope was obviously steep and prolonged. Plateau pikas living in hypoxia provide enough oxygen for its organism by lowering P50 and shifting ODC leftward.

关 键 词：高原鼠兔 高海拔低氧 氧解离曲线 血红蛋白氧饱和度 关键因子 希尔方程 

分 类 号：R96[医药卫生—药理学]