A型肉毒毒素膀胱内不同部位注射治疗女性膀胱疼痛综合征/间质性膀胱炎的临床研究  

Botulinum toxin type A injection on different positions of the bladder in female bladder pain syndrome/interstitial cystitis

作　　者：李杰荣 刘国庆 王剑锋 朵永福 张世林 李春景 

机构地区：[1]广东省佛山市人民西路11号妇幼保健院外科,广东佛山528000

出　　处：《国际泌尿系统杂志》2016年第5期722-725,共4页International Journal of Urology and Nephrology

基　　金：广东省卫生厅指令性课题（C2013014）;佛山市科技局基金项目（201308077）

摘　　要：目的 比较A型肉毒毒素膀胱内逼尿肌注射以及逼尿肌联合三角区注射两种不同注射方法治疗女性膀胱疼痛综合征/间质性膀胱炎的疗效以及安全性.方法 60例入选病例,随机分为两组：逼尿肌注射组（A组）、逼尿肌联合三角区注射组（B组）,评估两组患者治疗前及治疗后8周的平均每日排尿次数、最大排尿量、残余尿量、PUF评分、QOL评分.结果 A组及B组治疗后平均每日排尿次数减少,最大排尿量增加,PUF及QOL评分降低,残余尿量无明显增加,B组治疗后与A组治疗后相比,平均每日排尿次数、最大排尿量及PUF评分改善更明显,残余尿量与QOL评分无明显区别.结论 A型肉毒毒素膀胱内注射治疗女性膀胱疼痛综合征/间质性膀胱炎疗效好,生活质量提高,采用逼尿肌联合三角区部位的注射,症状缓解更为明显,副作用无明显增加,值得进一步研究及推广.Objectives To compare the different effects caused by different injection sites in bladder,in cases of female bladder pain syndrome/interstitial cystitis （BPS/IC） cured by botulinum toxin type A injection.Methods 60 cases were randomly divided into two groups.Cases of group A accepted botulinum toxin type A injection only on detrusor.Cases of group B accepted botulinum toxin type A injection on detrusor and trigone of urinary bladder.The following parameters were recorded to evaluate the effects after 8 weeks：average urination frequency,Maximum voiding,PUF scores and QOL scores.Results These parameters of two groups had no statistical differences before accepting treament.Efficacy in both groups obviously improved after treatment.Efficacy of group B improved more obviously than group A.Conclusions Botulinum toxintype A injection on bladder is a new effective method for female interstitial cystitis.Injection on detrusor and trigone of urinary bladder is better than injection only on detrusor.

关 键 词：膀胱炎 间质性 疼痛 综合征 肉毒杆菌毒素 A型 

分 类 号：R694[医药卫生—泌尿科学]