注射用鼠神经生长因子治疗腹股沟疝修补术后切口疼痛的临床研究  

Clinical study of mouse nerve growth factor for injection in the treatment of incision pain after inguinal hernia repair

作　　者：吕清泉[1] 童仕伦[1] 

机构地区：[1]武汉大学人民医院胃肠外科,430060

出　　处：《中国医师进修杂志》2016年第10期866-868,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的：探讨注射用鼠神经生长因子治疗腹股沟疝修补术后切口疼痛的可行性。方法将80例单侧腹股沟疝行腹股沟疝修补术患者按入选先后顺序分组，单号患者为对照组，双号患者为治疗组，每组40例。两组均行Lichtenstein无张力疝修补术，且术后均按腹股沟疝临床路径进行基础治疗，术后第3天对照组给予注射用水2 ml肌肉注射，治疗组给予注射用鼠神经生长因子20μg肌肉注射，14 d为1个疗程。分别于术后3 d、15 d、30 d、3个月、6个月进行随访，疼痛评估采用疼痛视觉模拟评分（VAS），疼痛范围依腹股沟区神经支配范围评定，疼痛对行为的影响采用六点行为等级评定量表（BRS-6）。结果两组术后3 d VAS、疼痛范围评分和BRS-6评分比较差异无统计学意义（P＞0.05）；治疗组术后15和30 d VAS、疼痛范围评分和BRS-6评分均明显低于对照组[术后15 d：（1.64±0.92）分比（2.28±1.06）分、（1.23±0.43）分比（1.61±0.56）分、（1.02±0.56）分比（1.57±0.73）分；术后30 d：（0.98±0.56）分比（1.61±1.04）分、（0.87±0.43）分比（1.16±0.56）分、（0.86±0.32）分比（1.16±0.73）分]，差异有统计学意义（P＜0.05）。两组术后3和6个月慢性疼痛发生率比较差异无统计学意义（P＞0.05）。结论腹股沟疝修补术后肌肉注射注射用鼠神经生长因子，可减轻术后切口疼痛。Objective To study the feasibility of mouse nerve growth factor for injection in treatment of incision pain after inguinal hernia repair. Methods Eighty unilateral inguinal hernia patients who had underwent inguinal hernia repair were divided into 2 groups according to the sequential order with 40 cases each. The patients of odd number were divided into control group, and the patients of dual number were divided into treatment group. All patients were performed Lichtenstein tension free repair operation, and were given the basic treatment of inguinal hernia. At the 3rd d after operation, the patients in control group were given 2 ml water for injection through intramuscular injection, and the patients in treatment group were given 20 μg mouse nerve growth factor for injection through intramuscular injection. One course of treatment was 14 d. At 3 d, 15 d, 30 d, 3 months and 6 months after operation, the pain degree, the pain range, and the effect of pain on behavior was observed and evaluated according to visual analogue score （VAS）, the innervation range of the inguinal region, and behavioral rating scale-6 （BRS-6） respectively. Results There were no statistical differences in VAS, pain range score and BRS-6 score 3 d after operation between 2 groups （P〉0.05）. The VAS, pain range score and BRS-6 score 15 and 30 d after operation in treatment group were significantly lower than those in control group, 15 d after operation：（1.64 ± 0.92） scores vs. （2.28 ± 1.06） scores, （1.23 ± 0.43） scores vs. （1.61 ± 0.56） scores and （1.02 ± 0.56） scores vs. （1.57 ± 0.73） scores, and 30 d after operation：（0. 98 ± 0.56） scores vs. （1.61 ± 1.04） scores, （0.87 ± 0.43） scores vs. （1.16 ± 0.56） scores and （0.86 ± 0.32） scores vs. （1.16 ± 0.73） scores, there were statistical differences （P〈0.05）. There were no statistical differences in the incidences of chronic pain 3 and 6 months after operation between 2 groups （P〉0.05）. Conclusions Injecting

关 键 词：疝 腹股沟 疼痛 手术后 注射用鼠神经生长因子 

分 类 号：R656.21[医药卫生—外科学]