Sesquiterpenes from Alisma plantago-aquatica  

泽泻中倍半萜类化合物（英文）

作　　者：Jingyi Yu Jun Wang Hong Liang Qingying Zhang Shizhong Chen Pengfei Tu 于京艺;王君;梁鸿;张庆英;陈世忠;屠鹏飞(北京大学医学部药学院天然药物及仿生药物国家重点实验室,北京100191;北京大学医学部药学院天然药物学系,北京100191)

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences Peking University Health Science Center, Beijing 100191, China

出　　处：《Journal of Chinese Pharmaceutical Sciences》2016年第8期614-620,共7页中国药学（英文版）

基　　金：The National Science and Technology Major Project of“Technological study on the safety and standards of Chinese materia medica”(Grant No.2014ZX09304307-001-011);Chinese materia medica supporting program of“Quality control base construction of Chinese material medica including Isatidis Radix,Carthami Flos,etc”by Ministry of Industry and Information Technology of Peoples Republic of China

摘　　要：Six sesquiterpenes, including three guaiane type sesquiterpenes （1-3）, one oplopanone type sesquiterpene （4）, one xanthane type sesquiterpene （5） and one salvialane type sesquiterpene （6）, were isolated from Alisma plantago-aquatica for the first time. The structures of these six compounds were elucidated as alismoxide （1）, alismol （2）, orientalol B （3）, oplopanone （4）, gibberodione （5）, and 7a, lOa-epoxy-salvialan-1Ofl-ol （6）, respectively, among which 6 was a new natural product. Xanthane type and salvialane type sesquiterpenes were obtained from the genus Alisma for the first time. In addition, a plausible biosynthetic pathway for all isolates was discussed.对泽泻中倍半萜类成分进行了研究,从中共分离得到3个愈创木烷型(1–3)、1个刺参烷型(4)、1个苍耳烷型(5)和1个鼠尾草烷型(6)倍半萜,其结构分别鉴定为泽泻薁醇氧化物(1),泽泻薁醇(2),东方泽泻醇(3),刺参烷醇(4),吉布洛萨软珊瑚二酮(5)和7α,10α-环氧鼠尾草烷-10β-醇(6),其中化合物6为新天然产物,苍耳烷型和鼠尾草烷型倍半萜为首次从泽泻属植物中分离得到。另外对分离所得倍半萜类成分的生源途径进行了合理推测。

关 键 词：Alismaplantago-aquatica SESQUITERPENES Biogenetic pathway 

分 类 号：R284[医药卫生—中药学]