丹参多酚酸盐对急性ST段抬高型心肌梗死患者血清中内脏脂肪素、基质金属蛋白酶-9及超敏C反应蛋白的影响  

The effects of visfatin, matrix metalloproteinases-9 and hypersensitive C-reactive protein by the treatment of depside salt from salvia miltiorrhiza in ST-segment elevation myocardial infarction patient

作　　者：郭功亮[1] 李晨昊[2] 孙立群[3] 

机构地区：[1]吉林大学第三医院心内科,长春130021 [2]吉林大学第一医院肾病科 [3]吉林大学第一医院儿科门诊

出　　处：《临床内科杂志》2016年第9期614-616,共3页Journal of Clinical Internal Medicine

摘　　要：目的通过检测急性ST段抬高型心肌梗死（STEMI）患者治疗前后血清内脏脂肪素（内脂素）、基质金属蛋白酶-9（MMP-9）、超敏C反应蛋白（hs-CRP）水平，探讨丹参多酚酸盐治疗STEMI中的机制。方法采用随机分组的方法，将100例STEMI患者随机分为2组，对照组50例和治疗组50例，测定患者治疗前后血清中内脂素、MMP-9、hs-CRP水平，另外选取50例非冠心病患者作为参考值组，采集血清中以上3种指标作为基础参考值。结果对照组及治疗组治疗后血清内脂素、MMP-9、hs-CRP水平均下降（P〈0．05），治疗组内脂素、MMP-9、hs-CRP降低幅度明显大于对照组（P〈0．05），且内脂素与MMP-9（r=0．583，P〈0．01）、hs-CRP（r=0．674，P〈0．01）均呈显著正相关。结论丹参多酚酸盐能显著降低急性STEMI患者血清中内脂素、MMP-9、hs-CRP，可能具有抗炎症反应、促进梗死周边心肌修复、抑制心室重构、改善预后等作用。Objective To investigate the treatment mechanism of depside salt from salvia miltior- rhiza in STEMI through detecting the levels of visfatin, matrix metalloproteinases-9 （ MMP-9 ） and hyper- sensitive C-reactive protein （hs-CRP） in serum before and after therapy of ST-segment elevation myocar- dial infarction（STEMI） patients. Methods 100 STEMI patients were divided into two groups randomly, 50 patients in control group and 50 patients in experimental group. Levels of visfatin, MMP-9 and hs-CRP in serum were detected. The patients without coronary heart disease served as another group and the levels of visfatin,MMP-9 and hs-CRP in this group were used as a basic reference value. Results The levels of visfatin, MMP-9 and hs-CRP decreased（ P 〈 0.05 ） in the control group and experimental group after treat- ment. The decreasing range of experimental group were higher than that in the control group （ P 〈 0.05 ）. Visfatin presented a notable positive correlation with MMP-9 （r = 0.583 ,P 〈 0.01 ）, and hs-CRP（ r = 0.674, P 〈 0.01 ）. Conclusion The depside salt from salvia miltiorrhiza can reduce the levels of visfatin, MMP-9 and hs-CRP in STEMI patients＇ serum. It has the abilities of anti-inflammatory, promotes myocardial repair in infarct periphery,inhibits ventricular remodeling and improves prognosis.

关 键 词：心肌梗死 内脏脂肪素 基质金属蛋白酶-9 超敏C反应蛋白 

分 类 号：R542.22[医药卫生—心血管疾病]