抗胆碱能药物联合经鼻／面罩双水平正压通气呼吸机治疗对重叠综合征患者生活质量影响的评估  

The life quality evaluation of COPD-OSAHS overlap syndrome patients treated with anticholinergic drugs and BiPAP ventilator

作　　者：江城[1] 李承红[2] 孟庆华[2] 孔彬[2] 

机构地区：[1]武汉市第一医院呼吸科,430022 [2]江汉大学附属医院武汉市第六医院呼吸科

出　　处：《临床内科杂志》2016年第9期617-619,共3页Journal of Clinical Internal Medicine

基　　金：武汉市卫生和计划生育委员会临床医学科研项目（WX14832）

摘　　要：目的探讨抗胆碱能药物噻托溴铵联合经鼻／面罩双水平正压通气（BiPAP）呼吸机治疗对重叠综合征（OS）患者生活质量的影响。方法将113例0s患者随机分为3组：试验组（38例），予以常规治疗＋BiPAP呼吸机＋噻托溴铵粉吸入治疗；对照组一（39例），予以常规治疗＋BiPAP呼吸机治疗；对照组二（36例），予以常规治疗＋噻托溴铵粉吸入治疗。比较治疗前后患者临床症状评分、Epworth嗜睡量表评分和6分钟步行试验结果有无差异。结果在临床症状评分、Epworth嗜睡量表评分和6分钟步行试验方面，3组治疗后较治疗前均明显改善（P〈0．05），其中试验组最为明显。结论采用噻托溴铵粉吸入联合BiPAP呼吸机治疗OS较单一治疗可更好改善患者的生活质量，值得在临床治疗中推广。Objective To investigate the effect of life quality in COPD-OSAHS overlap syndrome patients treated with anticholinergic drugs and BiPAP ventilator. Methods 113 patients with overlap syndrome（OS） were randomly divided into three groups： experimental group（38 patients） treated with conventional therapy ＋ BiPAP ventilator ＋ tiotropium bromide inhalation therapy, control group 1 （ 39 patients） treated with conventional therapy ＋ BiPAP ventilator, control group 2 （36 patients） treated with conventional therapy ＋ tiotropium bromide inhalation therapy. The clinical symptom scores, Epworth sleepiness scale scores and 6 minutes walk test results were compared before and after the treatment. Results There were significant differences in clinical symptom scores, Epworth sleepiness scale scores and 6 minutes walk test results in each group when compared before and after treatment （ P 〈 0.05 ） and the difference of the experimental group was the most among the three groups. Conclusion Compared with single therapy, combined treatment of BiPAP ventilator with tiotropium bromide inhalation can improve the life quality of patients, and should be widely used in clinical treatment.

关 键 词：重叠综合征 噻托溴铵粉吸入剂 经鼻/面罩双水平正压通气呼吸机 EPWORTH嗜睡量表 6分钟步行试验 

分 类 号：R563[医药卫生—呼吸系统]