检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:刘冉[1] 郝洪军[1] 刘琳琳[1] 罗晶晶[1] 闻洁曦[1] 高枫[1] LIU Ran HAO Hong-jun LIU Lin-lin LUO Jing-jing WEN Jie-xi GAO Feng(Department of Neurology, Peking University First Hospital, Beijing 100034, China)
出 处:《中国现代神经疾病杂志》2016年第9期566-572,共7页Chinese Journal of Contemporary Neurology and Neurosurgery
摘 要:炎症反应机制在动脉粥样硬化的发生与发展中发挥重要作用。多项基础与临床研究均提示炎性标志物表达变化与动脉粥样硬化程度密切相关,针对炎性因子的治疗可能给动脉粥样硬化患者带来益处。本文总结近年取得一些研究进展的传统和新型炎性标志物,如C-反应蛋白、白细胞介素-17、分泌型磷脂酶A2、脂蛋白相关磷脂酶A2、内皮糖蛋白、趋化因子受体和5脂氧合酶等,从基础与临床角度综述其作用机制和治疗前景。Inflammatory reaction plays a crucial role in the occurence and development of atherosclerosis.Both basic and clinical trials have provided evidence that the expression of inflammatory biomarkers are closely related with the degree of atherosclerosis.Treatment towards inflammatory factors would bring benefit to atherosclerotic patients.This review highlighted the mechanistic rationale and specific therapies targeting traditional and novel inflammatory biomarkers,including C- reactive protein(CRP),interleukin-17(IL-17),secretory phospholipase A2(sPLA2),lipoprotein-associated phospholipase A2(Lp- PLA2),endoglin,chemokine receptor and 5- lipoxygenase(5- LO),so as to review its mechanism of action and treatment prospect.
分 类 号:R543.5[医药卫生—心血管疾病]
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.3