上海市浦东新区慢性肾病流行情况及其危险因素研究  

Prevalence and Risk Factors of Chronic Kidney Disease among Residents from Pudong New Area,Shanghai

作　　者：刘晓琳[1] 周弋[1] 阮晓楠[1] 周先锋[1] 于思雨[1] 邱桦[1] 吴抗[1] 毕文婕[1] 芮欣忆[1] 王小楠[1] 柯居中[1] 肖林海[1] 郝莉鹏 孙乔[2] LIU Xiao - lin ZHOU Yi RUAN Xiao - nan ZHOU Xian - feng YU Si - yu QIU Hua WU Kang BI Wen -fie RUI Xin - yi WANG Xiao - nan KE Ju - zhong XIAO Lin - hai HAO Li - peng SUN Qiao(Chronic Diseases Control and Prevention Section, Center for Disease Control and Prevention of Pudong New Area, Fudan University Pudong Institute of Preventive Medicine, Shanghai 200136, China)

机构地区：[1]上海市浦东新区疾病预防控制中心复旦大学浦东预防医学研究院慢性病防治科,200136 [2]上海市浦东新区疾病预防控制中心复旦大学浦东预防医学研究院

出　　处：《中国全科医学》2016年第30期3742-3750,共9页Chinese General Practice

基　　金：浦东新区科技发展基金创新资金资助项目(PKJ2010-Y04)

摘　　要：目的调查上海市浦东新区居民慢性肾病（CKD）患病情况,并探究CKD的危险因素。方法在本课题组前期研究（2008年上海市浦东新区横断面调查人群）的基础上,以相同的多阶段抽样方法,抽取2013年浦东新区符合纳入标准的常住居民10 657例为调查对象。调查内容包括社区居民基本情况（性别、年龄、文化程度、静坐时间、睡眠时间、体育活动、糖尿病、高血压、血脂异常、向心性肥胖、高尿酸血症）;并对居民进行体格检查,记录其清蛋白尿、白细胞尿、肾功能下降、血尿、CKD患病率,其中肾损伤（清蛋白尿、白细胞尿、血尿）或肾功能下降〔估算肾小球滤过率（e GFR）〈60 ml·min^-1·（1.73 m^2）^-1〕或自报临床明确诊断中任意一项阳性均定义为CKD。以2010年全国人口构成对居民患病率进行标化。采用多因素Logistic回归分析分析居民患CKD的影响因素。结果 10657例调查对象中最终能够获得CKD结局的有效调查人数为9 653例,其中男3 550例（36.78%）,女6 103例（63.22%）。不同性别居民年龄、文化程度、静坐时间、睡眠时间、是否参加体育活动、糖尿病发生率、高血压发生率、血脂异常发生率、向心性肥胖发生率、高尿酸血症发生率比较,差异均有统计学意义（P〈0.05）。居民清蛋白尿患病率为12.10%（867/7 164）,全国人口标化患病化为9.22%。不同性别、睡眠时间及是否参加体育活动居民的清蛋白尿患病率比较,差异无统计学意义（P〉0.05）。不同年龄、文化程度、静坐时间,是否存在糖尿病、高血压、血脂异常、向心性肥胖、高尿酸血症居民的清蛋白尿患病率比较,差异有统计学意义（P〈0.05）。居民清蛋白尿患病率有随年龄增加而逐渐上升的趋势（χ_（趋势）^2=73.112,P〈0.05）;居民清蛋白尿患病率有随文化程度升高而逐渐降低的趋势（χ^2趋势=60.559,P〈0.05）。居民�Objective To investigate the prevalence and risk factors of chronic kidney disease（ CKD） among residents from Pudong New Area,Shanghai. Methods Based on the former study in 2008,10 657 permanent residents in Pudong New Area who met inclusion criteria,were selected as study subjects by multistage sampling in 2013. The contents of investigation included residents＇ basic information such as gender, age, education level, sitting time, sleeping time, status of physical activities,diabetes, hypertension, dyslipidemia, central obesity, and hyperuricemia. Physical and biochemical examination were also used in this study. The prevalence of albuminuria,leucocyturia,haematuria,reduced renal function and CKD were calculated. CKD definition included kidney injury（ albuminuria,leucocyturia,haematuria）,or reduced renal function 〔e GFR 60 ml·min^-1·（ 1. 73 m^2）^-1〕,or self- reported clinical diagnosis. The standardized prevalence was adjusted according to national population composition 2010. Multiple Logistic regression analysis was used to analyze the risk factors of CKD prevalence. Results 9 653 respondents had information about the ending of CKD among 10 657 respondents. Among 9 653 efficient respondents,3 550（ 36. 78%） were male and 6 103（ 63. 22%） were female. There were significant differences in age,education level,sitting time,sleeping time,physical activities,prevalence of diabetes,hypertension,dyslipidemia,central obesity and hyperuricemia between males and females（ P〈0. 05）. The prevalence and the standardized prevalence of albuminuria was 12. 10%（ 867 /7 164） and 9. 22%, respectively. There was no significant difference in prevalence of albuminuria among groups with different gender, sleeping time, and status of physical activities（ P〈0. 05）. There were significant differences in prevalence of albuminuria among groups with different age, education level, sitting time, status of diabetes,hypertension,dyslipidemia,central obesity and hyperuricemia（ P〈0. 05）. The preval

关 键 词：肾病 患病率 危险因素 横断面研究 流行病学 上海 

分 类 号：R256.59[医药卫生—中医内科学]