2014-2015年医院感染菌的分离及药敏分析  

Separation of bacteria in hospital from 2014 to 2015 and analysis of antimicrobial susceptibility

作　　者：华德兴[1] 蔡聪艺[2] 曾香连[1] 罗君[1] 蔡文灿[1] 何凤屏[1] 彭青[3] Hua De-xing Cai Cong-yi Zeng Xang lian Luo Jun Cai Wen-chan He Feng-ping Peng Qing(Department of Medical Laboratory, Yuebei People＇s Hospital, Affiliated to Shantou Medical College, Guangdong Shaoguan 512026 Department of Pharmacy, Second Affiliated Hospital, Shantou University Medical College, Guangdong Shantou 515041 Department of Hepatobiliary Surgery II, Zhujiang Hospital of Southern Medical University, Institute of Regenerative Medicine, Southern Medical University, Guangdong Guangzhou 510282)

机构地区：[1]汕头大学医学院附属粤北人民医院检验科,广东韶关512026 [2]汕头大学医学院第二附属医院药学部,广东汕头515041 [3]南方医科大学珠江医院肝胆二科南方医科大学再生医学研究所,广东广州510282

出　　处：《四川生理科学杂志》2016年第3期141-143,共3页Sichuan Journal of Physiological Sciences

基　　金：国家自然科学基金(编号:81202569);广东省普通高校青年创新人才项目

摘　　要：目的:分析粤北人民医院2014-2015年医院感染菌对临床常用抗生素的敏感性,为临床合理使用抗生素提供依据。方法:采用MIC法对两年分离菌进行药敏试验,应用WHONET 5.6和SPSS 13.0软件进行数据分析,并比较两年间抗生素敏感度变化。结果:我院分离的临床菌株对部分抗生素仍然保持高度敏感性,革兰阳性菌对替考拉宁、万古霉素、利奈唑胺、阿米卡星、呋喃妥因、高浓度庆大霉素均表现出较高的敏感率,而革兰阴性菌对多粘菌素B、头孢替坦、阿米卡星敏感率高;2014年与2015年相比,革兰阳性菌中氨苄西林、阿米卡星、米诺环素、克林霉素、复方新诺明比较有统计学意义(P<0.05),革兰阴性菌中哌拉西林、阿莫西林/克拉维酸、氨苄西林/舒巴坦、头孢曲松、头孢替坦、头孢西丁、头孢克洛、头孢哌酮/舒巴坦、氨曲南、亚胺培南、阿米卡星、米诺环素、氯霉素、复方新诺明比较有统计学意义(P<0.05)。结论:新推广使用的抗生素仍然有好的敏感性;合理使用抗生素有重要的意义。Objective：To investigate common antibiotic sensitivity against bacteria from 2014 to 2015in Yuebei People′s Hospital.Methods：Antibiotic sensitivity test was performed by minimal inhibitory concentration,and statistical result were analyzed by WHONET 5.6and SPSS 13.0software.Results：There were still highest sensitive rate in teicoplanin,vancomycin,linezolid,amikacin,macrodantin,high-level gentamicin from all gram-positive bacteria,and polymyxin b,cefotetan,amikacin from all gram-negative bacteria.Antibiotic sensitivity had statistic significance in ampicillin,amikacin,minocycline from gram-positive bacteria between 2014 and 2015,and piperacillin,amoxicillin/clavulanate,ampicillin/sulbactam,ceftriaxone,cefotetan,cefoxitin,cefaclor,cefoperazone/sulbactam,aztreonam,imipenem,amikacin,minocyline,chloramphenicol,selectrin from gram-negative bacteria.Conclusion：There are still good sensitivity in relatively new antibiotics and reasonable use of antibiotics has important significance.

关 键 词：医院感染菌 药敏试验 分析 

分 类 号：R446.5[医药卫生—诊断学] R197.32[医药卫生—临床医学]