小窝与血管内皮通透性  

Caveolae and vascular endothelial permeability

作　　者：田立俊 张军平[2] 仲爱芹[1] 王爱迪[1] 

机构地区：[1]天津中医药大学,天津300193 [2]天津中医药大学第一附属医院,天津300193

出　　处：《基础医学与临床》2016年第10期1433-1436,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(81173244)

摘　　要：小窝(caveolae)是调控血管内皮跨细胞通透性的关键分子,通过Cav-1的表达和磷酸化、Src激酶的激活及细胞旁转运调节血管的高通透性。caveolae及Cav-1参与低密度脂蛋白的跨细胞转运,调节血脑屏障,干预肿瘤病理性的血管新生及肺内皮屏障功能,有望为动脉粥样硬化和脑卒中等心脑血管疾病及某些癌症提供新的治疗靶点。Caveolae is the key molecule that regulates the permeability of vascular endothelial cells through Cav-1expression and phosphorylation,Src kinase activation and paracellular permeability. Caveolae and Cav-1 participate in the process of LDL transport across the cell,regulate the blood-brain barrier,interpose the tumor pathological angiogenesis and the pulmonary endothelial barrier,and provide new therapeutic targets for atherosclerosis,stroke and other cardiovascular and cerebrovascular diseases and certain cancers.

关 键 词：小窝 跨细胞转运 内皮通透性 治疗靶点 

分 类 号：R54[医药卫生—心血管疾病]