2型糖尿病患者肾血管阻力指数与血清Apelin水平的关系  

Relationship between renal vascular resistance index and serum apelin level in type 2 diabetic mellitus

作　　者：范玉娟[1] 李雪松[1] 郑徽[1] 任凤东[1] 沈春芳[1] 任国光[1] 杨架林[1] 

机构地区：[1]复旦大学附属闵行医院上海市闵行区中心医院内分泌科,201199

出　　处：《中国综合临床》2016年第8期684-686,共3页Clinical Medicine of China

基　　金：上海市科学技术委员会科研计划项目（15411970700）;上海市闵行区自然科学研究课题（11411980400）

摘　　要：目的：探讨T2DM患者肾血管阻力指数与血清Apelin水平的关系。方法选取2011年12月至2014年12月我院住院的17例新诊断T2DM肾血管阻力指数升高而24 h尿微量白蛋白正常者为观察组，另选取同期收治的17例新诊断T2DM肾血管阻力指数正常者为对照组。所有患者均测定FPG、HbA1c、血脂、胰岛素及肝、肾功能。采用酶联免疫分析法测定血清Apelin 浓度。结果与对照组比较，观察组血清Apelin水平明显升高[（179.2±122.4）μg／L与（56.7±50.6）μg／L]，差异有统计学意义（ t＝3.814，P＜0.05）。偏相关分析显示，肾血管阻力和Apelin呈正相关（ r＝0.364，P ＝0.040）。结论新诊断T2DM 肾血管阻力指数升高患者血清Apelin水平升高，且肾血管阻力指数和Apelin呈正相关，提示Apelin在2型糖尿病早期肾损害的病理生理中发挥重要作用。Objective To investigate the relationship between renal vascular resistance index（ RI） and serum Apelin level in type 2 diabetic mellitus （ T2DM ）.Methods Seventeen cases newly diagnosed T2DM patients with RI increased but without microalbuminuraia in Minhang Hospital Affiliated to Fudan University from December 2011 to December 2014 were selected as observation group,17 newly diagnosed T2DM patients with RI normal during the same period were selected as control group.Fasting plasma glucose（FPG）,glycosylated hemoglobin A1C（HbAlC）,blood lipids and fasting insulin（FINS）,hepatic functional and renal function were tested in all the subjects.Serum Apelin level was detected by enzyme.linked immunosorbent assay.Results Compared with control group,serum Apelin level was significantly higher in observation group（（179.2±122.4）μg/L vs.（56.7±50.6） μg/L,t=3.814,P〈0.05）.Partial correlation analysis showed that the RI was positive correlated with Apelin （ r= 0.364, P= 0.040 ）.Conclusion The serum Apelin levels elevated in newly diagnosed T2DM patients with RI increased, and RI is positively correlated with Apelin, which indicate that Apelin play an important role in the pathophysiology of early renal damage in patients with TsDM.

关 键 词：2型糖尿病 肾血管阻力 APELIN 

分 类 号：R544.1[医药卫生—心血管疾病]