经皮导管动脉化疗栓塞术联合无水酒精瘤内注射治疗原发性巨大肝癌40例效果观察  

Efficacy analysis of transcatheter arterial chemoembolization combined with conventional percutaneous ethanol injection therapy in the treatment of 40 cases of primary liver cancer

作　　者：宋诏民[1] 杨佳丽[2] 刘子凤[1] 尹承慧[1] 周大敏[1] 

机构地区：[1]河北省秦皇岛市第三医院肿瘤科,066000 [2]山东省淄博市齐都医院消化内科

出　　处：《中国综合临床》2016年第8期723-725,共3页Clinical Medicine of China

摘　　要：目的：探讨经皮导管动脉化疗栓塞术（ TACE）联合无水酒精瘤内注射（ PEIT）治疗巨大肝癌的效果。方法选取秦皇岛市第三医院2007年1月至2013年5月收治的原发性巨大肝癌（直径≥8 cm）患者40例，按随机数字表法将40例患者分成治疗组（20例）和对照组（20例）。对照组行TACE治疗，治疗组行TACE联合PEIT治疗，观察两组患者的临床效果。结果治疗组治疗有效率为80％，明显高于对照组50％，两组比较差异有统计学意义（ P＝0.04）；随访3年，对照组3例发生门脉癌栓；5例肝内转移，其中上消化道出血死亡1例，肝功能衰竭死亡2例。治疗组发现1例肝内转移，肝功能衰竭死亡1例。结论 TACE联合PEIT治疗原发性巨大肝癌可提高疗效，减少肝功能损害，是治疗巨大肝癌的一种姑息性有效手段。Objective To study the curative effect of transcatheter arterial chemoembolization（ TACE） combined with conventional percutaneous ethanol injection therapy （ PEIT） in the treatment for primary liver cancer.Methods Forty cases patients with primary liver cancer（the diameter was equal or more than 8 cm） who were treat in the Third Hospital of Qinhuangdao from January 2007 to May 2013 were selected,and randomly divided into treatment group（20 cases） and control group（20 cases）.The control group underwent TACE,the treatment group were given TACE combined with PEIT, the clinical effect of the two groups were observed.Results The effective rate of the treatment group was 80%,significantly higher than that of the control group（ 50%） ,the difference was statistically significant（ P=0.04）.During the follow.up of 3 years,there were 3 cases of portal vein tumor thrombus,5 cases of hepatic metastasis,1 case of upper gastrointestinal bleeding and 2 cases of liver failure in the control group;there were 1 case of liver metastasis,1 case of liver failure and death in the treatment group.Conclusion The test of the curative effect of patients with huge hepatocellular carcinoma after combination therapy with TACE and PEIT proved combination therapy can increase the curative effect, decrease impairment of liver funvtion.It was a palliation road to treat huge hepatocellular carcinoma.

关 键 词：经皮导管动脉化疗栓塞术 无水酒精瘤内注射法 肝癌 

分 类 号：R144.1[医药卫生—公共卫生与预防医学]