胰高血糖素样肽1受体激动剂对血糖波动和氧化应激的影响  

Effect of glucagon like peptide 1 receptor agonist on blood glucose fluctuation and oxidative stress

作　　者：薛慧[1] 李强[2] 

机构地区：[1]哈尔滨医科大学附属第二医院内分泌代谢病科一病区,150086 [2]哈尔滨医科大学附属第二医院糖尿病医院

出　　处：《中国综合临床》2016年第8期746-749,共4页Clinical Medicine of China

基　　金：国家自然科学基金（81170744,81370902）

摘　　要：氧化应激通过影响多种信号传导通路，诱导炎症反应，促进组织、细胞损伤和凋亡，参与糖尿病及其并发症的发生发展。血糖波动可加剧氧化应激，加重组织损伤凋亡。胰高血糖素样肽-1（ GLP-1）受体激动剂特异性的与其受体结合，发挥多系统生理效应，延缓胃排空、降低食欲、减少食物摄入量及减轻体质量，增强葡萄糖依赖性的胰岛素分泌、抑制葡萄糖依赖性的胰高血糖素分泌，改善血糖波动。另外，GLP-1通过自身调控功能，降低活性氧簇，抑制氧化酶活性，上调抗氧化防御相关基因，增加抗氧化酶水平，减轻氧化应激状态。Objective Oxidative stress which participates in the development of diabetes and its complications can induce inflammation and increase the damage and apoptosis on cells and tissue by influencing multiple signaling pathways-Blood glucose fluctuation increased oxidative stress and aggravated damage and apoptosis on cells.The roles of glucagon-like peptide-1 （ GLP-1） receptor agonist can improve blood glucose fluctuation by playing multiple system physiological effects,such as,delaying gastric emptying,reducing appetite, food intake and body weight, enhancing glucose dependent insulin secretion, inhibiting glucose dependent glucagon secretion-In addition,GLP-1 can reduce oxidative stress state by reducing the reactive oxygen species, inhibiting oxidase activity,up-regulating anti-oxidative stress genes,increasing the level of antioxidant enzymes.

关 键 词：胰高血糖素样肽1受体激动剂 血糖 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]