面向生物医学应用的光学氧气纳米传感器  

Optical Oxygen Nanosensors Towards Biomedical Applications

作　　者：彭洪尚[1,2] 申睿颖 王小卉[1] 

机构地区：[1]北京交通大学理学院,北京100044 [2]中央民族大学理学院,北京100081

出　　处：《发光学报》2016年第10期1167-1176,共10页Chinese Journal of Luminescence

基　　金：国家自然科学基金(61575017);教育部新世纪优秀人才支持计划(12-0771)资助项目

摘　　要：在生物医学领域,溶氧的检测具有十分重要的意义。近年来氧气传感器的研究取得了重要的进展,尤其是纳米尺寸的光学氧气传感器倍受重视。光学氧气纳米传感器具有检测灵敏度高、稳定性好、易于生物功能化等优点,特别适用于在(亚)细胞层次或者生物组织内溶氧的实时检测。本文主要从氧气荧光探针的种类、传感器的基质构成、纳米传感器的构建方法、检测模式和生物医学应用等几个方面出发,结合本研究组在光学氧气纳米传感器的研究进展进行综述,并对其在生物医学领域中的主要应用进行了阐述。The determination of oxygen concentration is of great importance in biological applications. In recent years,significant progress has been made in the field,and nanosized optical oxygen sensors have gained particular attraction owing to the merit of high sensitivity,good photostability,facile bioconjugation and ideal dimension for in vitro and in vivo applications. In this review,we focus on optical oxygen nanosensors,including the types of suitable oxygen probes,structure properties,preparation methods,and different detection modalities. In addition,for different O2 nanosensors,the analytical performance and applicability in specific biological applications are also outlined. Generally this review is meant to give the potential user a guide to select the most suitable optical oxygen nanosensor and detection modalities for their particular biological detection.

关 键 词：光学纳米传感器 氧气传感 磷光猝灭 生物医学成像 

分 类 号：O433.4[机械工程—光学工程] O482.31[理学—光学]