卵巢纤维化影响因素及相关疾病研究进展  

The influence factors and related diseases of ovarian fibrosis

作　　者：赵丹[1] 吕春梅[1] 朱辉[1] 金宏波[1] 

机构地区：[1]哈尔滨医科大学生理学教研室,黑龙江哈尔滨150081

出　　处：《解剖科学进展》2016年第5期523-525,共3页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81571957);黑龙江省自然科学基金(C201439);中国博士后科学基金(2014M551267);黑龙江省博士后科学基金(LBH-Z13142)

摘　　要：卵巢纤维化严重威胁女性生殖健康和生活质量,是造成卵巢功能衰退的原因之一。转化生长因子β1、结缔组织生长因子、血管内皮生长因子、缩血管性细胞因子等生长因子是刺激卵巢组织发生纤维化的主要因素。纤维化的表现可出现在放化疗后、卵巢早衰、糖尿病以及多囊卵巢综合症的卵巢组织中。本文就卵巢纤维化及其影响因素,以及卵巢纤维化的相关疾病作一简要介绍。Ovarian fibrosis is a serious threat to the reproductive health and quality of life in women, and is one of the reasons for the decline of ovarian function. Growth factors such as transforming growth factor- β 1, connective tissue growth factor and vascular endothelial growth factor are the main factors stimulating ovarian fibrosis. Ovarian fibrosis can be observed after chemotherapy and radiotherapy, premature ovarian failure, diabetes mellitus and polyeystic ovarian syndrome. This paper will introduce the ovarian fibrosis and its influencing factors, and research progress of ovarian fibrous related diseases.

关 键 词：卵巢纤维 多囊卵巢综合症 纤维化程度 卵巢早衰 生长因子 卵泡膜 性细胞 功能衰退 女性生殖健康 多囊卵巢综合征 

分 类 号：R711.75[医药卫生—妇产科学]