2型糖尿病周围神经病变的危险因素研究  

An analysis of the risk factors of diabetic peripheral neuropathy

作　　者：郝运[1] 何金鹏[1] 余学锋[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《内科急危重症杂志》2016年第4期259-261,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:探讨2型糖尿病并周围神经病变的相关危险因素。方法:收集糖尿病周围神经病变(DPN)组79例,非DPN(NDPN)组82例,均行口服葡萄糖耐量试验(OGTT)、血红蛋白、血脂检测等,比较2组血脂的差异。结果:DP N组与NDP N组的糖化血红蛋白水平、OGTT、胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMAIR),定量胰岛素敏感性检测指数(QUICKI),Matsuda胰岛素敏感性指数(ISI_M),Gutt胰岛素敏感性指数(ISI_G),总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)结果无统计学差异(均P>0.05)。DPN组血高密度脂蛋白(HDL)水平较NDPN组显著降低(P<0.05)。结论:血高密度脂蛋白(HDL)水平降低是DPN的高危因素,而年龄、病程、体重量指数(BMI)、收缩压、舒张压;TC、TG、LDL;糖化血红蛋白;OGTT试验结果;HOMA-β、HOMA-IR、QUICKI、ISI_M、ISI_G均不是DPN的危险因素。Objective： To explore the risk factors of diabetic peripheral neuropathy（ DPN）. Methods： Seventy-nine patients were divided into the DPN group,and 82 patients were included in the non-DPN group. OGTT was done,and hemoglobin and blood lipid were tested. The differences in blood lipid between two groups were compared. Results： There were no statistically significant differences in hemoglobin A1c（ Hb A1c）,OGTT results,HOMA-β,HOMA-IR,QUICKI,ISIM,ISIG,TC,TG and LDL between two groups（ P〉0. 05）. HDL was significantly lower in DPN group than in non-DPN group（ P〈0. 05）. Conclusion： Type 2 DPN may be associated with lower HDL but not with others,for example,age,history,body mass index,systolic blood pressure,diastolic blood pressure,TC,TG,LDL,Hb A1 c,OGTT results,HOMA-β,HOMA-IR,QUICKI,ISIM and ISIG.

关 键 词：2型糖尿病周围神经病变 危险因素 高密度脂蛋白 

分 类 号：R587.1[医药卫生—内分泌]