围生期因素对早产儿出生后早期肾功能的影响  

INFLUENCE OF PERINATAL FACTORS ON RENAL FUNCTION IN PRETERM INFANTS

作　　者：陈虹[1] 钟丹妮[2] 韦露明[2] Chen Hong ZhongDanni Wei Luming(Department of Pediatrics, the First Affiliated Hospital of Guan- gxi Medical University, Nanning 530021 , China)

机构地区：[1]广西医科大学 [2]广西医科大学第一附属医院儿科,南宁530021

出　　处：《广西医科大学学报》2016年第5期787-790,共4页Journal of Guangxi Medical University

基　　金：广西壮族自治区卫生厅自筹经费科研课题青年基金资助项目(No.Z2012063)

摘　　要：目的:探讨不同围生期因素对早产儿出生后早期肾功能的影响。方法:选取2012年1月至2015年12月广西医科大学第一附属医院新生儿病区收治的早产儿125例,根据围生期因素分为窒息组、妊娠期糖尿病(GDM)组、妊娠期高血压(HDCP)组、胎膜早破组及对照组,每组25例。记录各组患儿出生后第1、第7天的血清尿素氮(BUN)、肌酐(Cr)、胱抑素C(Cys-C)水平,观察各组患儿尿量、液体摄入量、蛋白质摄入量,分析结果及相关影响因素。结果:第1天窒息组、HDCP组BUN、Cr水平高于对照组,差异有统计学意义(P<0.05)。第7天HDCP组BUN、Cr、Cys-C低于第1天,差异有统计学意义(P<0.05)。胎膜早破组及对照组第7天的BUN较第1天升高,差异有统计学意义(P<0.05)。第1和第7天各组Cys-C比较差异无统计学意义(P>0.05)。各组出生后第1天液体摄入量比较,差异有统计学意义(P<0.05);各组第7天液体摄入量及第1、第7天尿量比较,差异无统计学意义(P>0.05)。各组第1天静脉蛋白摄入量比较,差异无统计学意义(P>0.05);各组第7天静脉蛋白摄入量比较差异有统计学意义(P<0.05),肠道蛋白摄入量比较差异无统计学意义(P>0.05);各组第1、第7天蛋白总摄入量比较差异无统计学意义(P>0.05)。相关性分析表明,Cr与日龄呈负相关关系(r=-0.553,P<0.01)。结论:窒息、HDCP对早产儿出生后早期肾功能的影响明显,而GDM、胎膜早破未见明显影响。Objective To investigate the influence of perinatal factors on renal function in preterm infants.Methods： From January 2012 and December 2015, 125 premature infants in our hospital were included and divided into 5 groups, each with 25 cases according to five different perinatal factors： the the gestational diabetes mellitus （GDM） group, the pregnancy-induced hypertension （HDCP.） group, the premature rupture of membrane （PROM） group and the control group. The levels of serum urea nitrogen （BUN）, creatine （Or） and cystain C （Cys-C） on day 1 and day 7 after birth were recorded, and the related perinatal factors were analyzed. Results： The levels of BUN, Cr in the asphyxia group and HDCP group were higher than those in the control group on day 1 （ P 〈0. 05）. In HDCP group,and Cys-C on day 7 were lower than those on day 1 （ P 〈0. 05）. The BUN level in the PROM group and the control group on day 7 were much higher than that on day 1 （ P 〈0. 05）. No significant difference in Cys-C level on day 1 and day 7 among groups （ P 〉0. 05）. The Cr level was negatively correlated with age （ r = - 0. 553 , P 〈 0 . 01）. Conclusion： Asphyxia and HDCP are the factors that influencing the renal func-tion of preterm, whereas GDM and PROM have no evident effect.

关 键 词：早产儿 肾功能 围生期因素 尿素氮 肌酐 胱抑素C 

分 类 号：R722.6[医药卫生—儿科]