戈舍瑞林对比卵巢去势治疗绝经前晚期乳腺癌的Meta分析  

Goserelin versus ovarian surgery castration in premenopausal patients with advanced breast cancer:A meta-analysis

作　　者：高波[1,2,3] 苏金龙[4] 田金徽[1,2] 姜专基[3] 杨克虎[1,2] 

机构地区：[1]兰州大学循证医学中心基础医学院,甘肃兰州730000 [2]兰州大学第一临床医学院,甘肃兰州730000 [3]甘肃省肿瘤医院乳腺科,甘肃兰州730050 [4]兰州大学第二医院药学中心,甘肃兰州730030

出　　处：《甘肃医药》2016年第10期724-728,共5页Gansu Medical Journal

摘　　要：目的:比较戈舍瑞林与卵巢去势治疗绝经前晚期乳腺癌的疗效及副反应。方法:检索Cochrane Library、Pub Med、EM-BASE、CBM、CNKI和Wan Fang Data数据库,收集戈舍瑞林与手术去势治疗绝经前晚期乳腺癌的随机对照试验。依纳入标准选择文献,提取资料并评价纳入研究的方法学质量,使用Rev Man5.3软件行Meta分析。结果:纳入2个RCT,221例患者。Meta分析结果显示:戈舍瑞林与手术去势相比在随访4年的总生存(OS)、无失败生存(FFS)、总有效率(RR)及恶心呕吐、粒细胞减低、不良情绪发生率方面差异无统计学意义(OS:RR=1.14,95%CI:0.84-1.54;FFS:RR=1.01,95%CI:0.33-3.14;RR:RR=1.08,95%CI:0.86-1.35;恶心呕吐:RR=1.27,95%CI:0.66-2.44;粒细胞减少:RR=2.17,95%CI 0.81-5.76;不良情绪:RR=1.47,95%CI:0.84-2.56)。而戈舍瑞林治疗后潮热及外周组织水肿发生率高于手术去势(潮热:RR=1.37,95%CI:1.12-1.69;外周组织水肿:RR=4.65,95%CI:1.08-19.94)。结论:与手术去势相比戈舍瑞林未提高随访4年的OS、FFS及RR,而治疗副反应部分高于前者。Objective：To compared the effects and the side effects between goserelin and ovarian surgery castration in premenopaus-al patients with advanced breast cancer. Methods：The randomized controlled trials （RCTs） about goserelin compared with ovarian surgery castration in premenopausal patients with advanced breast cancer were searched in the following databases：Cochrane Library, PubMed, EM-BASE, CBM, CNKI and Wan Fang. The literature were screened according to inclusive criteria. Data were extracted and the quality of includ-ed studies were assessed, then meta-analysis was conducted by using RevMan5.3 software. Results：A total of 2 RCTS with 221 patients were included. The results of meta-analysis showed that goserelin was no statistical significance compared with surgery castration in OS, FFS, RR , nausea/vomiting, leukopenia and depression （OS：RR=1.14,95%CI：0.84-1.54;FFS：RR=1.01,95%CI：0.33-3.14;RR：RR=1.08,95%CI：0.86-1.35;nausea/vomiting：RR=1.27,95%CI：0.66-2.44;leukopenia：RR=2.17,95%CI：0.81-5.76;depression：RR=1.47,95%CI：0.84-2.56）. There were significant differences in hot flushes and edema （hot flushes：RR=1.37,95%CI：1.12-1.69;edema：RR=4.65,95%CI：1.08-19.94）. Conclu-sion：Compared with ovarian surgery castration, goserelin can not improve the OS, FFS, RR in the treatment of premenopausal patients with advanced breast cancer in the four years follow-up, and side effects are higher among goserelin than ovarian surgery castration.

关 键 词：乳腺癌 卵巢去势 戈舍瑞林 META分析 

分 类 号：R195.1[医药卫生—卫生统计学]