星点设计-效应面法优化苍艾油包合物-鼻用温敏原位凝胶制备工艺  

Optimization for Preparation Technology of Cangai Volatile Oil Dextrin Inclusion Compound/in situ Nasal Thermosensitive Gel by Central Composite Design-response Surface Method

作　　者：黄秋艳[1] 熊磊[1] 汪红梅[1] 陈柏君[1] 马云淑[1] 孔淑君 王辉[1] 

机构地区：[1]云南中医学院,云南昆明650500

出　　处：《中国中医药信息杂志》2016年第11期86-89,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金地区基金(81160534;81560740)

摘　　要：目的采用星点设计-效应面法优化苍艾油包合物-鼻用温敏原位凝胶的制备工艺。方法以泊洛沙姆407、泊洛沙姆188用量为考察因素,胶凝温度为评价指标,采用二次多项式模型描述评价指标与2个因素之间的数学关系,以此确定优化处方,并加以验证。结果根据二次多项式模型,发现2个考察因素与评价指标之间存在可信的定量关系,其中泊洛沙姆407、泊洛沙姆188的最佳用量分别为19.37%、2.73%。结论采用星点设计-效应面法得到了基于二次多项式的苍艾油包合物-鼻用温敏原位凝胶处方最优模型,处方工艺稳定可行,实现了该原位凝胶的处方优化。Objective To optimize the preparation technology of Cangai volatile oil dextrin inclusion compound/ in situ nasal thermosensitive gel by the central composite design-response surface method. Methods In the design, the investigation factors were the amounts of poloxamer 407 and poloxamer 188, and the evaluation index was the gel temperature. Quadratic models were used to evaluate the mathematic relation between the evaluation index and two investigation indexes to identify the optimum prescription, and then the optimum prescription was verified. Results According to the quadratic models, it was found that there was reliable quantitative relation between the evaluation index and two investigation indexes, among which the optimum dosage was 19.37% for poloxamer 407 and 2.73% for poloxamer 188. Conclusion The optimum model of Cangai volatile oil dextrin inclusion compound/ nasal thermosensitive gel can be obtained from central composite design-response surface method based on quadratic models. This method is reliable and feasible, which can realize the prescription optimization of the in situ gel.

关 键 词：苍艾挥发油 包合物 鼻用温敏原位凝胶 星点设计-效应面法 

分 类 号：R283.5[医药卫生—中药学]