不同经导管给药方案治疗颅内感染的临床疗效与安全性比较  

Comparison of efficacy and safety of different transcatheter treatment of intracranial infection

作　　者：林荔青[1] 钱苏荣[1] 王剑刃[1] 

机构地区：[1]江苏省苏州市立医院北区脑外科,江苏苏州215008

出　　处：《中国现代医生》2016年第26期40-42,45,共4页China Modern Doctor

摘　　要：目的探讨不同经导管给药方案治疗颅内感染的临床疗效和安全性,为相关疾病的治疗策略提供参考。方法 随机选取我院2013年11月-2015年1月收治的颅内感染患者50例,将其分为研究组和对照组。研究组采用侧脑室置管外引流持续室内灌注给药联合腰大池引流的方法,对照组采用腰大池持续置管引流联合鞘内灌注给药方法进行治疗。比较两组患者治疗前后的颅内压和脑脊液成分的变化、感染控制时间及其临床效果。结果治疗后,两组患者颅内压和脑脊液成分均显著改善,研究组颅内压和脑脊液成分改善情况优于对照组（P〈0.05）。研究组患者总有效率（92.00%）高于对照组（68.00%）（P〈0.05）。随访结果表明研究组后遗症发生率低于对照组,生活质量高于对照组（P〈0.05）。结论 采用侧脑室置管外引流持续脑室内灌注给药联合腰大池引流能有效控制颅内感染,缩短治疗时间,提高患者生活质量。Objective To evaluate the efficacy and safety of different transcatheter treatment of intracranial infection, provide reference for treatment of related diseases. Methods 50 patients with intracranial infection in our hospital from November 2013 to January 2015 were divided into the study group and the control group. The study group was treated with external ventricular drainage and continuous ventricle perfusion of lateral ventricular drainage infusion combined with lumbar drainage of fluid, the control group was treated with continuous lumbar drainage of fluid combined with intrathecal infusion. The changes of intracranial pressure, cerebrospinal fluid composition, infection control time and efficacy before and after treatment between the two groups were compared. Results After the treatment, the intracranial pressure and cerebrospinal fluid composition of the two groups were significantly improved, and the changes of the study group were more obvious （P〈0.05）. The total effective rate of the study group （92.00%） was significantly higher than that of the control group（68.00%）（P〈0.05）. Following up study showed the incidence of sequelae in the study group was lower, and the level of life quality was higher than those in the control group （P〈0.05）. Conclusion Lateral ventricle drainage ventricle infusion continued lumbar cerebrospinal fluid drainage can effectively control the intraeranial infection, shorten the treatment time and improve the life quality.

关 键 词：颅内感染 侧脑室置管外引流 灌注给药 生活质量 

分 类 号：R651.11[医药卫生—外科学]