人源醛酮还原酶AKR7A与疾病关系研究进展  

Research progress in relationship between AKR7A and disease

作　　者：张明刚[1] 杨军[1] 

机构地区：[1]西安交通大学第二附属医院输血科,西安710004

出　　处：《生物学杂志》2016年第5期90-93,共4页Journal of Biology

基　　金：国家自然科学基金(NSFC30872403);教育部新世纪优秀人才计划(NCET-10-0647)

摘　　要：醛酮还原酶超家族(aldo keto reductase superfamily,AKRs)在生物界分布广泛,参与体内醛酮类化合物的清除代谢,使醛或酮上的羰基转化成醇,其活性与多种疾病的发生发展密切相关。AKR7A是一种在生物活化(bioaetivation)及生物解毒(biodetoxifieation)中起到重要作用的酶。AKR7A家族中表达于人体的有AKR7A2和AKR7A3,主要就关于它们的研究进展进行综述。AKRs are widely distributed in nature,participates in the clear metabolism in the body and make the aldehyde or ketone carbonyl convert into alcohol,and their activityies are closely related to a wide variety of tumor. AKR7 A is an enzyme,plays an important role in bioaetivation and biodetoxifieation. AKR7A2 and AKR7A3 are two members of AKR7 and express in human body. This article mainly reviewed the progress of the research.

关 键 词：醛酮还原酶超家族 生物活化 生物解毒 

分 类 号：Q55[生物学—生物化学]